Rapid Screening of Phenolic Compounds with Anti-Enteritis Activity from Camellia oleifera Oil Using a Smurf Drosophila Model and Molecular Docking Methods

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期刊论文

作者：

Wang, Shuhao;Li, Yang;Lin, Xin*;Fu, Xiangjin;Zhong, Haiyan;...

通讯作者：

Fu, XJ;Lin, Xin

作者机构：

[Wang, Shuhao; Zhong, Haiyan; Fu, Xiangjin; Fu, XJ] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forest Edible Resources Safety, Changsha 410004, Peoples R China.

[Wang, Shuhao] Commod Qual Inspect Inst Hunan Prov, Changsha 410004, Peoples R China.

[Lin, Xin; Zhong, Haiyan; Fu, Xiangjin; Lin, X; Li, Yang; Fu, XJ; Ren, Kangzi] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

[Liu, Cheng] Yi Feng Agr & Forestry Technol Co Ltd, Shaoyang 422300, Peoples R China.

[Yao, Wen] Hunan Ju Xiong Inst Camellia oleifera Oil, Yueyang 414000, Peoples R China.

通讯机构：

[Lin, X; Fu, XJ ] C

Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forest Edible Resources Safety, Changsha 410004, Peoples R China.

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

语种：

英文

关键词：

Camellia oleifera;anti-enteritis activity;molecular docking;polyphenols;wighteone;p-octopamine

期刊：

Molecules

ISSN：

1420-3049

年：

2024

卷：

期：

页码：

76-

DOI：

10.3390/molecules29010076

基金类别：

This work was supported by the National Key Research and Development Program of China (No. 2022YFD2101303) and Hunan Provincial Key R&D Program Project (2022NK2032). Author Cheng Liu was employed by the company Yi-Feng Agriculture and Forestry Technology Co. Ltd. The authors declare that this study received funding from National Key Research and Development Program of China and Hunan Provincial Key R&D Program Project. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Screening and identifying the active compounds in foods are important for the development and utilization of functional foods. In this study, the anti-enteritis activity of ethanol extract from Camellia oleifera oil (PECS) was quickly evaluated using a Smurf Drosophila model and the metabolomics approach, combined with molecular docking techniques, were performed to rapidly screen and identify compounds with potential anti-enteritis activity in PECS. PECS showed good anti-enteritis activity and inhibited the activity of 5-lipoxygenase (LOX), cyclooxygenase 2 (COX-2) and inducible nitric oxide ...

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Rapid Screening of Phenolic Compounds with Anti-Enteritis Activity from Camellia oleifera Oil Using a Smurf Drosophila Model and Molecular Docking Methods

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