期刊论文

Tang, Hao

英文

Colloids and Surfaces B: Biointerfaces

0927-7765

2018

171

622-628

10.1016/j.colsurfb.2018.07.067

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21275050, 21145001]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [13JJ1016]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [13A053]; Construct Program of the Key Discipline in Hunan Province; Foundation of the Science & Technology Department of Hunan Province [2016SK2020]

本校为其他机构

The surface functional groups of GO have significant effects on the performances of GO-based gene delivery vector. In this work, the polyamidoamine (PAMAM) dendrimer and glycyrrhetinic acid (GA) were tethered onto the GO surface by one-step covalently cross-linking method. The micro-morphology, surface functional groups, and zeta potential of the obtained GO-PAMAM-GA hybrid were characterized and verified. The effects of GA amount in the hybrid on the dispersive property in cell culture medium, in vitro cytotoxicity to human hepatocarcinoma (SMMC-7721) and human embryonic kidney (HEK-293) cell...