Due to the complex and diverse terrains in China, the unequal height piers are commonly used for high-speed railway track-bridge system (HSRTBS). The unequal pier height may amplify the seismic responses of the components in HSRTBs. Besides, the energy dissipation steel device (EDSD) is suggested to control the damages. Therefore, how to balance the effect of the unequal pier height and the arrangement of these devices is an essential issue. This paper proposed U-shaped EDSD, and investigates how the device arrangements affect the seismic responses of 5-span 4-pier HSRTBs with three typical pi...