Efficient accumulation and in Vitro antitumor activities of triterpene acids from submerged batch-cultured lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes)

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Xiao-Ling;Ding, Zhong-Yang;Zhao, Yan;Liu, Gao-Qiang*;Zhou, Guo-Ying

通讯作者：

Liu, Gao-Qiang

作者机构：

[Liu, Gao-Qiang; Zhou, Guo-Ying; Zhao, Yan; Wang, Xiao-Ling] Cent South Univ Forestry Technol, Coll Life Sci & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha, Peoples R China.

[Ding, Zhong-Yang] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi, Peoples R China.

[Liu, Gao-Qiang; Zhou, Guo-Ying] Cent South Univ Forestry Technol, Hunan Prov Key Lab Control Forest Dis & Pests, Changsha, Hunan, Peoples R China.

[Liu, Gao-Qiang] 498 Southern Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Liu, Gao-Qiang] 4

498 Southern Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

ganoderic acid;Ganoderma lucidum extract;triterpene;unclassified drug;antineoplastic agent;ganoderic acid T;lanosterol;triterpene;antineoplastic activity;Article;batch fermentation;biomass production;chemical analysis;cytotoxicity;fungal biomass;Ganoderma lucidum;human;human cell;in vitro study;mathematical model;mortality;MTT assay;mycelial growth;nonhuman;response surface method;scale up;stirred reactor;submerged fermentation;validation process;analogs and derivatives;bioreactor;chemistry;fermentation;Ganoderma lucidum;isolation and purification;temperature;traditional medicine;tumor cell line;Antineoplastic Agents;Bioreactors;Cell Line, Tumor;Fermentation;Humans;Lanosterol;Medicine, Traditional;Reishi;Temperature;Triterpenes

期刊：

INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

ISSN：

1521-9437

年：

2017

卷：

期：

页码：

419-431

DOI：

10.1615/IntJMedMushrooms.v19.i5.40

基金类别：

Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-13-1046]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ1025]; Research Foundation of Education Bureau of Hunan Province, China [14K112]

机构署名：

本校为第一机构

院系归属：

林学院

生命科学与技术学院

摘要：

Triterpene acids are among the major bioactive constituents of Ganoderma lucidum. However, submerged fermentation techniques for isolating triterpene acids from G. lucidum have not been optimized for commercial use, and the antitumor activity of the mycelial triterpene acids needs to be further proven. The aim of this work was to optimize the conditions for G. lucidum culture with respect to triterpene acid production, scaling up the process, and examining the in vitro antitumor activity of mycelial triterpene acids. The key conditions (i.e., i...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Efficient accumulation and in Vitro antitumor activities of triterpene acids from submerged batch-cultured lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes)

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问