Oral administration of: Lentinus edodes β-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARγpathways

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成果类型：

期刊论文

作者：

Shi, Limin;Lin, Qinlu;Yang, Tao;Nie, Ying;Li, Xinhua;...

通讯作者：

Luo, Feijun

作者机构：

[Liu, Bo; Tang, Yiping; Luo, Feijun; Yang, Tao; Shi, Limin; Shen, Junjun; Nie, Ying; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Lab Mol Nutr, Coll Food Sci & Engn, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

[Li, Xinhua] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Luo, Feijun] C

Cent South Univ Forestry & Technol, Lab Mol Nutr, Coll Food Sci & Engn, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2016

卷：

期：

页码：

4614-4627

DOI：

10.1039/c6fo01043a

基金类别：

Project "Collaborative Innovation Center of Hunan Province" [448]; Key Project of the Education Department of Hunan Province [13A124]; Graduate Innovative Research Project of Hunan Province; Central South University of Forestry and Technology [122-0035, CX2013B14, CX2013B358, CX2016B23]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

To evaluate the anti-inflammatory effect of β-glucans from Lentinus edodes, and its molecular mechanism, the dextran sulfate sodium salt (DSS) induced colitis model of mice and the LPS-stimulated RAW264.7 cell inflammation model were used in this study. 40 ICR male mice were randomly divided into 4 groups: Control, DSS (DSS treated only), DSS + low-βGs (500 mg kg-1 d-1) and DSS + high-βGs (1000 mg kg-1 d-1). The body weight of the mice with Lentinus edodes β-glucan supplementation increased significantly compared to the DSS group and the di...

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Oral administration of: Lentinus edodes β-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARγpathways

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