Antifreeze protein (AFP) can protect organisms from damage in freezing conditions by controlling ice growth (thermal hysteresis activity) and inhibiting recrystallization of ice granules (recrystallization inhibition activity) respectively. Formerly, hydrogen-bonding matching model was used to explain the surface binding mechanism between AFPs and ices, however, it is only suitable for one or several AFPs, but not for the others. Therefore, basing on the newly developed mode of surface complementarity, we used bioinformatics methods, especially protein docking, to obtain the molecular models o...
