期刊论文

Role of the coagulation and fibrinolysis in acute lung injury

中文

中国病理生理杂志

Chinese Journal of Pathophysiology

1000-2502

2009

21

5

1026-1029

10.3321/j.issn:1000-4718.2009.05.041

本校为其他机构

急性肺损伤（acute lung injury，AU），以肺泡上皮细胞和血管内皮屏障损伤、急性炎症反应、富含蛋白的肺水肿为特征，是一种临床常见的危重病症，可进一步发展为急性呼吸窘迫综合症（acute respiratory distress syndrome，ARDS）。ALI／ARDS在临床上表现为进行性呼吸窘迫和顽固性低氧血症。病理表现为急性肺间质水肿，广泛的肺微血管内皮损伤、微血栓形成和肺泡内纤维蛋白沉着。ALI起病急剧，发展迅速，病情凶险，治疗困难，死亡率高，其机制复杂，至今尚未完全阐明。近年来研究发现，ALI／ARDS的发生与肺内凝血与纤维蛋白溶解作用异常密切相关。

Acute lung injury （ALl） and acute respiratory distress syndrome （ARDS） are common, life - threatening causes of acute respiratory failure that arise from a variety of local and systemic insults. The pathogenesis of ALI/ARDS is complicated and not yet completely interpreted today. The role of altered coagulation and fibrinolysis in the pathogenesis of ALI/ARDS has been investigated. This review will summarize the current understanding of coagulation and fibrinolysis in human ALI/ARDS with emphasis on pathways that could be potential therapeu...