Adopting a theophylline-responsive riboswitch for flexible regulation and understanding of glycogen metabolism in Synechococcus elongatus PCC7942

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成果类型：

期刊论文

作者：

Chi, Xintong;Zhang, Shanahan;Sun, Huili;Duan, Yangkai;Qiao, Cuncun;...

通讯作者：

Luan, Guodong;Lu, Xuefeng

作者机构：

[Zhang, Shanahan; Luan, GD; Lu, XF; Luan, Guodong; Lu, Xuefeng; Sun, Huili; Duan, Yangkai; Qiao, Cuncun; Chi, Xintong] Chinese Acad Sci, Key Lab Biofuels, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China.

[Zhang, Shanahan; Luan, GD; Lu, XF; Luan, Guodong; Lu, Xuefeng; Sun, Huili; Qiao, Cuncun; Chi, Xintong] Chinese Acad Sci Qingdao, Shandong Prov Key Lab Synthet Biol, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China.

[Chi, Xintong] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Changsha, Hunan, Peoples R China.

[Zhang, Shanahan; Sun, Huili; Qiao, Cuncun] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.

[Duan, Yangkai] Chinese Acad Sci, Shandong Prov Key Lab Energy Genet, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China.

通讯机构：

[Luan, GD; Lu, XF] C

[Lu, Xuefeng] D

[Lu, Xuefeng] Q

Chinese Acad Sci, Key Lab Biofuels, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China.

Chinese Acad Sci Qingdao, Shandong Prov Key Lab Synthet Biol, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Peoples R China.

语种：

英文

关键词：

GlgC;cyanobacteria;glycogen;photosynthesis;riboswitch;stress tolerance

期刊：

Frontiers in Microbiology

ISSN：

1664-302X

年：

2019

卷：

期：

MAR

页码：

551

DOI：

10.3389/fmicb.2019.00551

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant Nos. 31770092, 31600034, 31525002, 31761133008, and 31872624), the Shandong Provincial Natural Science Foundation (Grant No. ZR2017ZB0211), the Strategic Priority Research Program of the Chinese Academy of Sciences (Transformational Technologies for Clean Energy and Demonstration, XDA21010211), the Shandong Taishan Scholarship (to XL), and the Key Laboratory of Biofuels of Chinese Academy of Sciences.

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本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Cyanobacteria are supposed to be promising photosynthetic microbial platforms that recycle carbon dioxide driven into biomass and bioproducts by solar energy. Glycogen synthesis serves as an essential natural carbon sink mechanism, storing a large portion of energy and organic carbon source of photosynthesis. Engineering glycogen metabolism to harness and rewire carbon flow is an important strategy to optimize efficacy of cyanobacteria platforms. ADP-glucose pyrophosphorylase (GlgC) catalyzes the rate-limiting step for glycogen synthesis. Howev...

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Adopting a theophylline-responsive riboswitch for flexible regulation and understanding of glycogen metabolism in Synechococcus elongatus PCC7942

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