Anti-inflammatory diterpenes and steroids from peels of the cultivated edible mushroom Wolfiporia cocos

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期刊论文

作者：

Chen, Baosong;Wang, Sixian;Liu, Gaoqiang;Bao, Li*;Huang, Ying;...

通讯作者：

Bao, Li;Liu, Hongwei

作者机构：

[Bao, Li; Liu, Hongwei; Chen, Baosong; Zhao, Ruilin] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, 1 Beichenxi Rd, Beijing 100101, Peoples R China.

[Liu, Hongwei; Chen, Baosong] Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China.

[Wang, Sixian; Liu, Gaoqiang] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha, Peoples R China.

[Wang, Sixian; Liu, Gaoqiang] Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Re, Changsha, Peoples R China.

[Huang, Ying] Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, 1 Beichenxi Rd, Beijing, Peoples R China.

通讯机构：

[Bao, L; Liu, HW] C

Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, 1 Beichenxi Rd, Beijing 100101, Peoples R China.

语种：

英文

关键词：

Wolfiporia cocosditerpene;Steroid;Anti-Inflammatory;Antimicrobial activity

期刊：

Phytochemistry Letters

ISSN：

1874-3900

年：

2020

卷：

页码：

11-16

DOI：

10.1016/j.phytol.2020.01.005

基金类别：

National Key R&D program of China [2018YFD0400203, 2017YFE0108200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673334]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Chemical investigation on the peels of the cultivated edible mushroom Wolfiporia cocos led to the identification of 13 diterpenes and 4 steroids, including two new abietane diterpenes (1 and 2) and one new pregnane steroid (14). Structures of new compounds were determined by analysis of NMR, MS, and electronic circular dichroism (ECD) data. All compounds were evaluated for cytotoxicity (K562 and HepG2), antimicrobial and anti-inflammatory activity. Compounds 15, 17 showed strong cytotoxicity on K562 cells with the IC50 values of 5.4 and 7.5 mu M, respectively. Compounds 4, 9 and 17 displayed m...

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Anti-inflammatory diterpenes and steroids from peels of the cultivated edible mushroom Wolfiporia cocos

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