Antiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling

成果类型：

期刊论文

作者：

Cui, Xiaoji;Lin, Qinlu*;Huang, Ping;Liang, Ying*

通讯作者：

Lin, Qinlu;Liang, Ying

作者机构：

[Cui, Xiaoji; Huang, Ping; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Mol Nutr Branch, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Lin, QL; Liang, Y] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Mol Nutr Branch, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Tissue regeneration;Transcription;Tumors;Anti-tumor activities;Biological process;Blood glucose level;Embryonic development;Epithelial-mesenchymal transition;Lipopolysaccharides;Mesenchymal cells;Pathological process;Cell signaling;antineoplastic agent;herbaceous agent;Ras protein;transforming growth factor beta;Wnt protein;antineoplastic activity;epithelial mesenchymal transition;human;MAPK signaling;nonhuman;Review;signal transduction;TGF beta signaling;tumor hypoxia;Wnt signaling;epithelial mesenchymal transition;epithelium cell;gene expression regulation;genetics;metabolism;neoplasm;physiology;signal transduction;Blood;Cells;Control Systems;Development;Glucose;Processes;Tumors;Epithelial Cells;Epithelial-Mesenchymal Transition;Gene Expression Regulation;Humans;Neoplasms;Signal Transduction

期刊：

Oxidative Medicine and Cellular Longevity

ISSN：

1942-0900

年：

2020

卷：

2020

页码：

1-10

DOI：

10.1155/2020/9253745

基金类别：

Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibrosis. EMT mechanisms, including gene mutation and transcription factor regulation, are complicated and not yet well understood. In this review, we introduce some herbal active substances that exert antitumor activity through inhibiting EMT that is induced by hypoxia, high blood glucose level, lipopolysaccharide, or other factors. Grain-Oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province Hunan Youth Excellent Talents Supporting Program 2016RS3033 National Natural Science Foundation of China 31571874 31201348

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibrosis. EMT mechanisms, including gene mutation and transcription factor regulation, are complicated and not yet well understood. In this review, we introduce some herbal active substances that exert antitumor activity through inhibiting EMT that is in...

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问