Protective Effect of Tangeretin and 5-Hydroxy-6,7,8,3′,4′-Pentamethoxyflavone on Collagen-Induced Arthritis by Inhibiting Autophagy via Activation of the ROS-AKT/mTOR Signaling Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Guliang;Xia, Xinxin;Zhong, Haiyan*;Shen, Junfeng;Li, Shiming*

通讯作者：

Zhong, Haiyan;Li, Shiming

作者机构：

[Yang, Guliang; Zhong, Haiyan; Xia, Xinxin] Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & Byprod Proc, Changsha 410004, Hunan, Peoples R China.

[Shen, Junfeng; Li, Shiming] Huanggang Normal Univ, Hubei Key Lab EFGIR, Huanggang 438000, Hubei, Peoples R China.

通讯机构：

[Zhong, Haiyan] C

[Li, Shiming] H

Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & Byprod Proc, Changsha 410004, Hunan, Peoples R China.

Huanggang Normal Univ, Hubei Key Lab EFGIR, Huanggang 438000, Hubei, Peoples R China.

语种：

英文

关键词：

Cell death;Collagen;Mammals;Transmission electron microscopy;Autoimmune disease;Collagen-induced arthritis;Immunofluorescence staining;Molecular mechanism;Pathological process;Protective effects;Protective potentials;Rheumatoid arthritis;Diseases;5-hydroxy-6,7,8,3',4'-pentamethoxyflavone;collagen type 2;flavone derivative;protective agent;protein kinase B;reactive oxygen metabolite;tangeretin;target of rapamycin kinase;animal;apoptosis;autophagy;bovine;cell proliferation;drug effect;female;genetics;human;metabolism;pathophysiology;rat;rheumatoid arthritis;signal transduction;Sprague Dawley rat;synovium;Animals;Apoptosis;Arthritis, Rheumatoid;Autophagy;Cattle;Cell Proliferation;Collagen Type II;Female;Flavones;Humans;Protective Agents;Proto-Oncogene Proteins c-akt;Rats;Rats, Sprague-Dawley;Reactive Oxygen Species;Signal Transduction;Synovial Membrane;TOR Serine-Threonine Kinases

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2021

卷：

期：

页码：

259-266

DOI：

10.1021/acs.jafc.0c06801

基金类别：

This work was supported by the Research Foundation of Hunan Education Bureau of China (No. 19A13) and the scientific research project of Central South University of Forestry and Technology (No. 2020YJ0001) and Grant from Hubei Province, China (GRANT number 2019ABA100).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Rheumatoid arthritis (RA) is an autoimmune disease characterized by long duration and repeated relapse. This study explored the preventive effect of tangeretin (TAN) and 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone (5-HPMF) on RA, and the underlying molecular mechanism based on a rat model stimulated by bovine type II collagen (BIIC). After the intervention of TAN or 5-HPMF (TAN/5-HPMF) for 5 weeks, the RA lesions and autophagy levels of the synovial tissue were significantly reduced, and the ROS content and HO-1 expression level were down-regul...

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Protective Effect of Tangeretin and 5-Hydroxy-6,7,8,3′,4′-Pentamethoxyflavone on Collagen-Induced Arthritis by Inhibiting Autophagy via Activation of the ROS-AKT/mTOR Signaling Pathway

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