Reconstruction and analysis of a genome-scale metabolic model of Ganoderma lucidum for improved extracellular polysaccharide production

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成果类型：

期刊论文

作者：

Ma, Zhongbao;Ye, Chao;Deng, Weiwei;Xu, Mengmeng;Wang, Qiong;...

通讯作者：

Ding, Zhongyang

作者机构：

[Ma, Zhongbao; Ye, Chao; Xu, Mengmeng; Wang, Qiong; Liu, Liming; Xu, Zhenghong; Shi, Guiyang; Ding, Zhongyang] Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi, Peoples R China

[Ma, Zhongbao; Ye, Chao; Deng, Weiwei; Xu, Mengmeng; Wang, Qiong; Liu, Liming; Xu, Zhenghong; Shi, Guiyang; Ding, Zhongyang] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi, Peoples R China

[Liu, Gaoqiang] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Key Lab Cultivat & Protect NonwWood Forest Trees, Minist Educ, Changsha, Hunan, Peoples R China

[Wang, Feng] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Peoples R China

通讯机构：

[Ding, Zhongyang] J

Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi, Peoples R China. Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi, Peoples R China.

语种：

英文

关键词：

Ganoderma lucidum;biosynthetic pathway;extracellular polysaccharide;genome-scale metabolic model;phenylalanine;simulation

期刊：

Frontiers in Microbiology

ISSN：

1664-302X

年：

2018

卷：

期：

DEC

页码：

ARTN 3076

DOI：

10.3389/fmicb.2018.03076

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31271918]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M571691]; Qing Lan ProjectJiangsu Polytech Institute

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本校为其他机构

院系归属：

林学院

生命科学与技术学院

摘要：

In this study, we reconstructed for the first time a genome-scale metabolic model (GSMM) of Ganoderma lucidum strain CGMCC5.26, termed model iZBM1060, containing 1060 genes, 1202 metabolites, and 1404 reactions. Important findings based on model iZBM1060 and its predictions are as follows: (i) The extracellular polysaccharide (EPS) biosynthetic pathway was elucidated completely. (ii) A new fermentation strategy is proposed: addition of phenylalanine increased EPS production by 32.80% in simulations and by 38.00% in experiments. (iii) Eight gene...

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Reconstruction and analysis of a genome-scale metabolic model of Ganoderma lucidum for improved extracellular polysaccharide production

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