The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Jie;Zhang, Xueyu;Wang, Tao;Li, Jinghong;Su, Qi;...

通讯作者：

Chen, Zhongshu;Liang, Ying

作者机构：

[Li, Jie; Li, Jinghong; Zhong, Cheng; Zhang, Xueyu] Jiangxi Chest Hosp, Dept Internal Med, Nanchang 330006, Peoples R China.

[Chen, Zhongshu; Wang, Tao] Jiangxi Chest Hosp, Dept Thorac Surg, Nanchang 330006, Peoples R China.

[Su, Qi] Jiangxi Chest Hosp, Med Dept, Nanchang 330006, Peoples R China.

[Liang, Ying] Cent South Univ Forestry & Technol, Dept Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Chen, Zhongshu] J

[Liang, Ying] C

Jiangxi Chest Hosp, Dept Thorac Surg, Nanchang 330006, Peoples R China.

Cent South Univ Forestry & Technol, Dept Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

advanced glycation end product;high mobility group B1 protein;immunoglobulin enhancer binding protein;long untranslated RNA;microRNA;microRNA 627;synaptotagmin I;transforming growth factor beta1;unclassified drug;high mobility group B1 protein;HMGB1 protein, human;immunoglobulin enhancer binding protein;long untranslated RNA;microRNA;MIRN155 microRNA, human;MIRN627 microRNA, human;TGFB1 protein, human;transforming growth factor beta1;Article;cell activation;cell proliferation;controlled study;epithelial mesenchymal transition;extracellular matrix;fibroblast;gene expression;human;human cell;immunoblotting;immunohistochemistry;immunoprecipitation;in vivo study;lung fibrosis;pathogenesis;protein phosphorylation;case control study;cell proliferation;cytology;fibroblast;gene expression regulation;genetics;lung;lung fibrosis;metabolism;pathology;signal transduction;Case-Control Studies;Cell Proliferation;Extracellular Matrix;Fibroblasts;Gene Expression Regulation;HMGB1 Protein;Humans;Lung;MicroRNAs;NF-kappa B;Pulmonary Fibrosis;RNA, Long Noncoding;Signal Transduction;Transforming Growth Factor beta1

期刊：

Life Sciences

ISSN：

0024-3205

年：

2021

卷：

269

期：

页码：

119085

DOI：

10.1016/j.lfs.2021.119085

基金类别：

This study was supported by the National Natural Science Foundation of China ( 81960019 ), the Natural Science Foundation of Hunan Province (No. 2020JJ4138 ), Hunan Furong Scholars Program, Huxiang Youth Talents Supporting Program (No. 2016RS3033 ) and Scientific Research Foundation of Hunan Provincial Education Department (No. 18A160 ). This study was supported by the National Natural Science Foundation of China (81960019), the Natural Science Foundation of Hunan Province (No. 2020JJ4138), Hunan Furong Scholars Program, Huxiang Youth Talents Supporting Program (No. 2016RS3033) and Scientific Research Foundation of Hunan Provincial Education Department (No. 18A160).

机构署名：

本校为通讯机构

院系归属：

食品科学与工程学院

摘要：

Nature Reviews' clinical content is written by internationally renowned clinical academics and researchers and targeted towards readers in the medical sciences, from postgraduate level upwards. While intended to be read by practicing doctors, researchers and academics within a specialty, we aim to make all our articles accessible to readers working in any medical discipline. In-depth Reviews present authoritative, up-to-date information on a topic, placing it in the context of a field's history and development. Topical discussion and opinions a...

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The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition

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