Exploring the multifaceted roles of histone deacetylase inhibitor vorinostat in the cell growth, mycelial morphology, pigments, and citrinin biosynthesis of Monascus purpureus.

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成果类型：

期刊论文

作者：

Run-Ya Li;Chen-Yu Zhang;Shaoxiang Xiao;Xin-Yi Liu;Ru-Xue Li;...

通讯作者：

Jun Liu

作者机构：

[Run-Ya Li; Ru-Xue Li; Chen-Yu Zhang; Xin-Yi Liu; Hao Li; Jing Li] Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China

[Shaoxiang Xiao] Hunan Vocational College of Science and Technology, Changsha, 410004, Hunan, China

[Jun Liu] Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China. liujundandy@csuft.edu.cn

通讯机构：

[Jun Liu] H

Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, China

语种：

英文

关键词：

M. purpureus;Monascus pigments;Citrinin;Histone acetylation;Morphology;Vorinostat

期刊：

Archives of Microbiology

ISSN：

0302-8933

年：

2025

卷：

207

期：

页码：

1-17

DOI：

10.1007/s00203-025-04300-8

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 32101906), and the Science and Technology Innovation Program of Hunan Province (Grant No. 2022RC1018).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Acetylation is an important modification type of histones, which is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this study, the histone acetylation level of Monascus was enhanced through the exogenous addition of the HDACs inhibitor vorinostat, and the regulation effects of histone acetylation on cell growth and secondary metabolism were evaluated. The results demonstrated that the augmentation of histone acetylation level could slightly facilitate sugar consumption, increase biomass weight, a...

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Exploring the multifaceted roles of histone deacetylase inhibitor vorinostat in the cell growth, mycelial morphology, pigments, and citrinin biosynthesis of Monascus purpureus.

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