A dual-site modulated FRET-based two-photon ratiometric fluorescent probe for tracking lysosomal pH changes in living cells, tissues and zebrafish

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期刊论文

作者：

Zhao, Xiongjie;Wang, Chao;Yuan, Gangqiang;Ding, Haiyuan;Zhou, Liyi*;...

通讯作者：

Zhou, Liyi

作者机构：

[Zhao, Xiongjie] Cent S Univ, Dept Pharmaceut Engn, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.

[Yuan, Gangqiang; Zhou, Liyi; Ding, Haiyuan; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Proc Food Special Med Purpose,Coll, Changsha 41004, Hunan, Peoples R China.

[Liu, Xiaogang; Wang, Chao] Singapore Univ Technol & Design, 8 Somapah Rd, Singapore 487372, Singapore.

通讯机构：

[Zhou, Liyi] C

Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Proc Food Special Med Purpose,Coll, Changsha 41004, Hunan, Peoples R China.

语种：

英文

关键词：

Two-photon ratiometric imaging;Lysosomal pH changes;Tissues zebrafish

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2019

卷：

290

页码：

79-86

DOI：

10.1016/j.snb.2019.03.122

基金类别：

Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21605046]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ3060]; Science and Technology Innovation Platform and Talent Project of Hunan Province [2017TP1021]

机构署名：

本校为通讯机构

院系归属：

食品科学与工程学院

摘要：

Lysosomal pH plays an essential role in mediating various biological processes such as immunization, cell metabolism and enzyme activity. Herein, by utilizing the fluorescence resonance energy transfer (FRET) strategy, a two-photon (TP) ratiometric fluorescent probe (NpLys-pH) has been developed for tracking of lysosomal pH changes in living cells, tissues, and zebrafish. NpLys-pH was constructed by conjugating a pH turn-on TP fluorophore 1 (D-p-A-structured naphthalene derivative) with a pH turn-off naphthalimide fluorophore 2 via a non-conjugated linker. Meanwhile, NpLys-pH has two potential...

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A dual-site modulated FRET-based two-photon ratiometric fluorescent probe for tracking lysosomal pH changes in living cells, tissues and zebrafish

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