期刊论文

Fu, Da;Jiang, Zong-Yuan;Lin, Qin-Lu

英文

信号转导与靶向治疗

2095-9907

2020

5

1

417-419

10.1038/s41392-020-0143-9

We thank Wen Li, Pei Luo, Hui-Qiong Yang, Cheng-You Jia, Hui-Deng Long, Ru-Ting Xie, and Jun-Jian Jiang for contributions to cytological experiments; Yu Sun and Qiong Ye for contributions to western blot and antibody production; and Ping Zhou and Pei Zhang for contributions to the techniques involving cell lines and mice. This study was supported partly by grants from the National Natural Science Foundation of China (81972214, 81772932, 81201535, and 81302065), Scientific Research Fund Project of Anhui Medical University (2018xkj058), Construction of Clinical Medical Center for Tumor Biological Samples in Nantong (HS2016004), and Jiangsu 333 Program (BRA2017205).

本校为通讯机构

Dear Editor,Tumor-suppressor protein p53 is important for cell function and genome integrity.1 The decrease of p53 protein is a common feature of human malignant tumors,which leads to the deficiency of cell cycle detection point control and apoptosis induction.An enormous amount of research effort goes into small molecules that regulate p53,including wild-type repair of mutant p53 gene and interruption of the binding between p53 and an E3-ubiquitin ligase Mdm2 to prevent ubiquitination degradation of p53 and rescue the protein level of p53.2 However,it is not clear whether it is necessary to c...