Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy.

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成果类型：

期刊论文

作者：

Zou, Jianmei;Shi, Muling;Liu, Xiaojing;Jin, Cheng;Xing, Xiaojing;...

通讯作者：

Qiu, Liping

作者机构：

[Shi, Muling; Zou, Jianmei; Qiu, Liping; Liu, Xiaojing; Jin, Cheng; Xing, Xiaojing; Tan, Weihong] Hunan Univ, Aptamer Engn Ctr Hunan Prov, State Key Lab Chemo Biosensing & Chemometr, Coll Life Sci,Coll Chem & Chem Engn,Mol Sci & Bio, Changsha 410082, Hunan, Peoples R China.

[Tan, Weihong] Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Gainesville, FL 32611 USA.

[Tan, Weihong] Univ Florida, Univ Hlth Canc Ctr, UF Genet Inst, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA.

[Tan, Weihong] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA.

[Shi, Muling] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Qiu, Liping] H

Hunan Univ, Aptamer Engn Ctr Hunan Prov, State Key Lab Chemo Biosensing & Chemometr, Coll Life Sci,Coll Chem & Chem Engn,Mol Sci & Bio, Changsha 410082, Hunan, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2019

卷：

期：

页码：

2425-2430

DOI：

10.1021/acs.analchem.8b05204

基金类别：

NSFCNational Natural Science Foundation of China (NSFC) [91753109, 21505039, 2016QNRC001]; HPNSFC [2018JJ3034]; CPSFChina Postdoctoral Science Foundation [2017M622567]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GM R35 127130, NSF1645215]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R35GM127130] Funding Source: NIH RePORTER

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本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Exosomes (Exos) are nanoscale natural vehicles for transporting biomolecules to facilitate cell-to-cell communication, indicating a high potential of them for delivering therapeutics/diagnostics. To improve their delivery capacity, a simple, noninvasive, and efficient strategy for functionalizing Exos with effective targeting ligands as well as elucidation of the cellular uptake mechanism of these functionalized Exos was found be to necessary, but remained a challenge. In this work, we used diacyllipid-aptamer conjugates as the targeting ligand...

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Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy.

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