Prevention of Oxidative Stress by alpha-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro

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成果类型：

期刊论文

作者：

He, Liuqin;Wu, Jian;Tang, Wenjie;Zhou, Xihong*;Lin, Qinlu;...

通讯作者：

Zhou, Xihong;Li, Tiejun

作者机构：

[Yin, Yulong; He, Liuqin] Hunan Normal Univ, Hunan Int Joint Lab Anim Intestinal Ecol & Hlth, Lab Anim Nutr & Human Hlth, Coll Life Sci, Changsha 410081, Hunan, Peoples R China.

[Zhou, Xihong; Wu, Jian; Zhou, XH; Li, Tiejun; Yin, Yulong; He, Liuqin] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Inst Subtrop Agr,Natl Engn Lab Pollut Control & W, Changsha 410125, Hunan, Peoples R China.

[Luo, Feijun; He, Liuqin; Lin, Qinlu] Ctr South Univ Forestry & Technol, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

[Li, Tiejun; Yin, Yulong] Hunan Coinnovat Ctr Anim Prod Safety, CICAPS, Changsha 410128, Hunan, Peoples R China.

[Tang, Wenjie] Sichuan Acad Anim Sci, Anim Breeding & Genet Key Lab Sichuan Prov, Chengdu 610066, Sichuan, Peoples R China.

通讯机构：

[Zhou, XH; Li, TJ] C

[Li, Tiejun] H

Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Inst Subtrop Agr,Natl Engn Lab Pollut Control & W, Changsha 410125, Hunan, Peoples R China.

Hunan Coinnovat Ctr Anim Prod Safety, CICAPS, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

alpha-ketoglutarate;piglets;constitutive androstane receptor;antioxidant enzymes;oxidative stress

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2018

卷：

期：

页码：

11273-11283

DOI：

10.1021/acs.jafc.8b04470

基金类别：

National Key Research and Development Program of China [2018YFD0500405]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31872371, 31472106, 31702125]; Key Research and Development Programs of Hunan Province [2017NK2321]; Open Fund of the Key Laboratory of Agro-ecological Processes in Subtropical Region, Chinese Academy of Sciences [ISA2018204]; Key Programs of Frontier Scientific Research of the Chinese Academy of Sciences [QYZDY-SSW-SMC008]

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

alpha-Ketoglutarate (AKG) can act as an antioxidant both in vitro and in vivo. However, the mechanisms of the protective effects of AKG are still not well understood. We evaluated the effects of AKG supplementation on the regulation of the constitutive-androstane-receptor (CAR) pathway in porcine intestinal cells and piglets exposed to H2O2. Our data showed that AKG treatment significantly increased not only the intra- and extracellular levels of AKG (26.9 +/- 1.31 mumol/g protein, 1064.4 +/- 39.80 mumol/L medium) but also those of Asp (29.3 +/- 0.21 mumol/g, 4.20 +/- 0.11 mumol/L), Gln (24.82...

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Prevention of Oxidative Stress by alpha-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro

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