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Spent hen-derived ACE inhibitory peptide IWHHT shows antioxidative and anti-inflammatory activities in endothelial cells

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成果类型:
期刊论文
作者:
Gu, Yuchen;Liang, Ying;Bai, Jie;Wu, Wei;Lin, Qinlu*;...
通讯作者:
Wu, Jianping;Lin, Qinlu
作者机构:
[Wu, Jianping; Gu, Yuchen] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
[Wu, Wei; Bai, Jie; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Engn, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Wu, Jianping] U
[Lin, Qinlu] C
Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
Cent South Univ Forestry & Technol, Coll Food Engn, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
Spent hen;ACE inhibitory activity;Gastrointestinal digestion;Antioxidative activity;Anti-inflammatory activity;Endothelial cells
期刊:
Journal of Functional Foods
ISSN:
1756-4646
年:
2019
卷:
53
页码:
85-92
基金类别:
Natural Sciences and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada
机构署名:
本校为通讯机构
院系归属:
食品科学与工程学院
摘要:
The pathophysiology of hypertension involves the interplay among renin-angiotensin system (RAS), oxidative stress and inflammation. Previous studies focused mainly on ACE inhibitory activity; the goals of this study were to characterize ACE inhibitory peptides from chicken and to investigate their potential antioxidative and anti-inflammatory activities. Spent hen muscle protein hydrolysate digested by thermolysin showed an IC50 value of 39.6 ± 2.3 µg/mL. Following HPLC fractionation and LC-MS/MS analysis, a potent ACE inhibitory peptide IWHH...

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