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Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer

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成果类型:
期刊论文
作者:
Ma, Yu-Shui;Li, Wen;Liu, Yu;Shi, Yi;Lin, Qin-Lu*;...
通讯作者:
Lin, Qin-Lu;Fu, Da
作者机构:
[Fu, Da; Ma, Yu-Shui; Li, Wen; Lin, Qin-Lu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & By Prod Deep Proc, Changsha, Peoples R China.
[Shi, Yi; Liu, Yu; Fu, Da; Ma, Yu-Shui] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Cent Lab Med Res, Shanghai 200072, Peoples R China.
通讯机构:
[Lin, Qin-Lu] C
[Fu, Da] T
Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & By Prod Deep Proc, Changsha, Peoples R China.
Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Cent Lab Med Res, Shanghai 200072, Peoples R China.
语种:
英文
关键词:
CRC;CSC;CCSCs;targeted therapy;drug resistance
期刊:
Technology in Cancer Research & Treatment
ISSN:
1533-0346
年:
2020
卷:
19
基金类别:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported partly by grants from the National Natural Science Foundation of China (81972214, 81772932, 81472202, 81201535, 81302065, 81671716, 81301993, 81372175, and 81472209), The Fundamental Research Funds for the Central Universities (22120170212 and 22120170117), Shanghai Natural Science Foundation (12ZR1436000), and Shanghai Municipal Commission of Health and Family Planning (201540228).
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
As one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cancer, is still not satisfactory. More and more evidence shows that tumors are likely to be a stem cell disease. In recent years, the rise of cancer stem cell theory has provided a new way for cancer treatment. Studies have found that a small number of special cells in colorectal cancer tissues that ind...

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