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CsA Promotes XIST Expression to Regulate Human Trophoblast Cells Proliferation and Invasion Through miR-144/Titin Axis

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成果类型:
期刊论文
作者:
Yu, Nanhui;Liang, Ying;Zhu, Hong;Mo, Hongying*;Pei, Haiping*
通讯作者:
Pei, Haiping;Mo, Hongying
作者机构:
[Pei, Haiping; Zhu, Hong; Yu, Nanhui] Cent S Univ, Dept Gastrointestinal Surg, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.
[Yu, Nanhui] Changsha Hosp Maternal & Child Hlth Care, Dept Pharm, Changsha 410007, Hunan, Peoples R China.
[Liang, Ying] Cent South Univ Forestry & Technol, Dept Food Sci & Engn, Changsha 410007, Hunan, Peoples R China.
[Mo, Hongying] Changsha Hosp Maternal & Child Hlth Care, Dept Gynaecol, 416 ChengNan East Rd, Changsha 410007, Hunan, Peoples R China.
通讯机构:
[Pei, Haiping; Mo, Hongying] C
Cent S Univ, Dept Gastrointestinal Surg, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.
Changsha Hosp Maternal & Child Hlth Care, Dept Gynaecol, 416 ChengNan East Rd, Changsha 410007, Hunan, Peoples R China.
语种:
英文
关键词:
connectin;cyclosporin A;long untranslated RNA;microRNA;microRNA 144;mitogen activated protein kinase;unclassified drug;connectin;cyclosporin;long untranslated RNA;matrix metalloproteinase;microRNA;MIRN144 microRNA, human;mitogen activated protein kinase;XIST non-coding RNA;Article;cell invasion assay;cell isolation;cell proliferation;correlation coefficient;ectopic expression;gene expression regulation;gene interaction;genetic transfection;human;human cell;human cell culture;priority journal;protein expression;RNA gene;signal transduction;trophoblast;Western blotting;x inactive specific transcript;cell motion;cytology;drug effects;genetics;metabolism;trophoblast;tumor cell line;Blotting, Western;Cell Line, Tumor;Cell Movement;Cell Proliferation;Connectin;Cyclosporine;Humans;Matrix Metalloproteinases;MicroRNAs;Mitogen-Activated Protein Kinases;RNA, Long Noncoding;Trophoblasts
期刊:
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN:
0730-2312
年:
2017
卷:
118
期:
8
页码:
2208-2218
机构署名:
本校为其他机构
院系归属:
食品科学与工程学院
摘要:
In our previous study, we revealed that Cyclosporin A (CsA) could inhibit miR-144 expression to regulate proliferation and invasion of human trophoblast (HT) cells through miR-144 targeting titin. This partially demonstrated the mechanism by which CsA promotes titin expression to increase the vitality of HT cells. However, the mechanism by which CsA inhibits miR-144 expression remains to be investigated. Recently, the interaction between lncRNA and miRNA has been frequently reported to play major role in several biological processes. In the pre...

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