In Situ imaging of orthotopic kidney cancer in the murine model using an aminopeptidase N activatable fluorescent probe

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成果类型：

期刊论文

作者：

Lu, Danqing;Yuan, Bingzhen;Ye, Qiaozhen;Hu, Cong;Liu, Hongwen

通讯作者：

Lu, DQ;Liu, HW

作者机构：

[Yuan, Bingzhen; Lu, Danqing; Lu, DQ] Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Hunan, Peoples R China.

[Hu, Cong; Liu, Hongwen; Ye, Qiaozhen] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China.

[Yuan, Bingzhen; Lu, Danqing] Yuelushan Lab High Qual Timber Forests Variety Inn, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Lu, DQ ] C

[Liu, HW ] H

Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Hunan, Peoples R China.

Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China.

语种：

英文

关键词：

Kidney Cancer;Fluorescent probe;Alminopeptidase N;Near-infrared fluorescence;In situ imaging

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2023

卷：

395

页码：

134494

DOI：

10.1016/j.snb.2023.134494

基金类别：

CRediT authorship contribution statement Danqing Lu: Investigation, Methodology, Data curation, Writing – original draft. Bingzhen Yuan: Formal analysis. Qiaozhen Ye: Investigation, Formal analysis. Cong Hu: Writing – review & editing. Hongwen Liu: Data curation, Conceptualization, Supervision, acquisition, Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

理学院

摘要：

Surgical treatment is the most effective treatment for renal cancer. It is urgent to develop highly selective and sensitive analytical methods for specially lighting up the kidney tumor, so as to achieve accurate imaging-guided surgical resection of cancer tissue. However, the main challenge in real-time and in situ fluorescence imaging of kidney tumor rest with the design of fluorescent probes that not only show renal metabolic pathway to enrich in the kidney cancer cells but also have high activatable signal towards kidney tumor-associated biomarkers. Since aminopeptidase N (APN) acted as a ...

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In Situ imaging of orthotopic kidney cancer in the murine model using an aminopeptidase N activatable fluorescent probe

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