Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation

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成果类型：

期刊论文

作者：

Shen, Yingbin;Song, Xun;Li, Li;Sun, Jian;Jaiswal, Yogini;...

通讯作者：

Guan, Yifu

作者机构：

[Shen, Yingbin; Song, Xun] Univ Minnesota, Coll Pharm, Ctr Drug Design, Minneapolis, MN 55455 USA.

[Shen, Yingbin] Jinan Univ, Sch Sci & Engn, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China.

[Li, Li; Sun, Jian] Guangxi Acad Agr Sci, Agrofood Sci & Technol Res Inst, Nanning 530007, Guangxi, Peoples R China.

[Li, Li; Sun, Jian] Guangxi Key Lab Fruits & Vegetables Storage Proc, Nanning 530007, Guangxi, Peoples R China.

[Huang, Junqing] Jinan Univ, Formula Pattern Res Ctr, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China.

通讯机构：

[Guan, Yifu] T

Temple Univ, Dept Chem, Philadelphia, PA 19122 USA.

语种：

英文

关键词：

p-Courmaric acid;Antioxidant activity;Oxidative stress;PC12 cells;High fat-diet mice model

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

111

页码：

579-587

DOI：

10.1016/j.biopha.2018.12.074

基金类别：

This research work was financially supported by China Postdoctoral Science Foundation funded project (Grant No. 2016M602605 ) and Natural Science Foundation of China (Grant No. 31701594 , 21402166 and 31670360 ).

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

Dietary phenols are antioxidants with diverse physiological functions that are beneficial for human health. The objective of this research work was to investigate antioxidant activity of p-coumaric acid (p-CA) using four in vitro methods, the protective effects against oxidative stress in PC12 cells, and hypolipidemic effects on High fat-diet (HFD) mice model. The p-CA exhibited moderate antioxidant activity in the selected in vitro assay. The highest chelating activity of p-CA at 50 mug/mL was found to be 52.22%. Pretreatment with p-CA significantly enhanced cell viability of PC12 cell and su...

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Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation

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