期刊论文

中文

食品与机械

1003-5788

2013

29

2

68-72

10.3969/j.issn.1003-5788.2013.02.015

国家质量监督检验检疫总局质检公益性行业科研专项（编号：201110061-03） 湖南省大学生研究性学习与创新性实验计划（编号：2011-165）

本校为第一机构

对食品药品包装材料中常用抗氧化剂2,6-二叔丁基对甲苯酚(BHT)、四[β-(3,5-二叔丁基-4-羟基苯基)丙酸]季戊四醇酯(Irganox1010)、β-(3,5-二叔-4-羟基苯基)丙酸正十八碳醇酯(Irganox1076)、三(2,4-二叔丁基苯基)亚磷酸酯(Irgafos168)安全性进行毒理学评价。采用急性毒性试验、小鼠骨髓微核试验、小鼠精子畸形试验和30 d喂养试验进行毒性评价。结果表明:小鼠经口LD_(50)等于11 340 mg/kg.BW;小鼠骨髓微核试验、小鼠精子畸形试验结果为阴性;30 d喂养试验未见大鼠的生长发育、血液学、生化、脏器比及组织病理学有异常变化。4种抗氧化剂混合物急性毒性分级属无毒级,无染色体损伤作用,无精子损害作用...

Objective： The toxicological assessments were investigated to evaluate the safety of BHT, Irganoxl010, Irganox1076 and Irgafos168, which were the common used antioxidants in the food and pharmaceuti- cal packaging materials. Methods： The acute toxicity test, micronucleus test of born marrow in mice, sperms shape abnormality test in mice and thirty-day feeding test in rats were used in the toxicological assess- ments. Results： The oral LD~o of mice is 11 340 mg/kg＇BW; the results of micronucleus test of born marrow in mice and sperms shape a...