Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Guang;Xie, Wenqing;Li, Hengzhen;Lu, Wenhao;Liang, Ying;...

通讯作者：

Xiao, WF;Wang, YP

作者机构：

[Xiao, Wenfeng; Xie, Wenqing; Yang, Guang; Lu, Wenhao; Li, Hengzhen; Li, Yusheng; Xiao, WF] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

[Liang, Ying] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & By Prod Deep Proc, Mol Nutr Branch, Changsha 410008, Hunan, Peoples R China.

[Xiao, Wenfeng; Li, Yusheng; Xiao, WF] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Dept Geriatr, Changsha 410008, Hunan, Peoples R China.

[Wang, YP; Wang, Yaping] Cent South Univ, Teaching & Res Sect Clin Nursing, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Wang, YP ; Xiao, WF ] C

Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Dept Geriatr, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Teaching & Res Sect Clin Nursing, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Circulating metabolites;OA;MR;LDSC;Genetic Correlation

期刊：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES

ISSN：

1449-1907

年：

2025

卷：

期：

页码：

2609-2619

DOI：

10.7150/ijms.111848

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

The causal impact of blood metabolites on OA has yet to be definitively established, further studies are needed to explore the specific roles of metabolites in OA. This is a genetic correlation and two-sample bidirectional mendelian randomization study. GWAS summary data of metabolites and OA were extracted from large-scale GWAS study based on Europeans and Asians. LDSC was conducted to estimate the genetic correlations between 233 circulating metabolites and 11 OA phenotypes, MR was then performed to explore the casual association. 41.20% of the metabolic traits showed genetic correlation wit...

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Deciphering the Relationship Between Circulating Metabolites and Osteoarthritis: A Comprehensive Genetic Correlation and Mendelian Randomization Studies

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