期刊论文

Shi Muling;Liu Gaoqiang

中文

高等学校化学学报

0251-0790

2021

42

11

3493-3508

10.7503/cjcu20210458

Supported by the the Scientific Research Project of Education Department of Hunan Province for Distinguished Young Scholars, China(No.18B179) and the Natural Science Foundation of Hunan Province, China(No.2020JJ5976).

本校为第一且通讯机构

自研究者证实外泌体承担了细胞外RNA等物质的运输功能以来,关于外泌体来源与功能的研究一直备受关注.近年来外泌体被发现具有作为疾病生物标志物的潜力,使得拥有特定表面蛋白以及特定装载物的外泌体成为分析化学领域有价值的检测对象.从化学本质角度来说,外泌体的获取与分析需要依赖特异性的分子识别过程.核酸适体作为分子识别单元,因其特异性强、亲和力高、生物活性稳定、易于合成和保存、而且其序列和结构上具有可编程性,易于设计和修饰,已成功地用在外泌体相关的生物传感体系中.本文从外泌体的化学组成及其具有生理、病理意义的组分出发,从外泌体通用生物标志物识别、癌细胞来源外泌体的检测...

Exosomes are globular bodies with lipid bilayer membrane structure secreted by living cells. Since researchers have confirmed that the exosomes undertake the function of extracellular RNA transportation, the research on the origin and function of exosomes is in the ascendant. In recent years, exosomes have been found to have the potential to be disease biomarkers, which makes exosomes with specific surface proteins and specific carriers become valuable detection objects in biomedical science. From the perspective of chemical essence, the acquis...