Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line

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成果类型：

期刊论文

作者：

Liu, Kuijie;Chen, Weidong;Lei, Sanlin;Xiong, Li;Zhao, Hua;...

通讯作者：

Yao, Hongliang;Liang, Ying

作者机构：

[Liu, Kuijie; Lei, Zhendong; Xiong, Li; Zhou, Nanjiang; Chen, Weidong; Yao, Hongliang; Lei, Sanlin; Zhao, Hua] Cent S Univ, Xiangya Hosp 2, Dept Gen Surg, Changsha 410011, Hunan, Peoples R China.

[Liang, Dong] Zhengzhou Univ, Peoples Hosp, Henan Prov Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China.

[Liang, Ying] Cent South Univ Forestry & Technol, Dept Food Sci & Engn, Shaoshan South Rd 498, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Yao, Hongliang; Liang, Ying] C

Cent S Univ, Xiangya Hosp 2, Dept Gen Surg, Changsha 410011, Hunan, Peoples R China.

Cent South Univ Forestry & Technol, Dept Food Sci & Engn, Shaoshan South Rd 498, Changsha 410004, Hunan, Peoples R China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2017

卷：

期：

页码：

e3096

DOI：

10.1038/cddis.2017.477

基金类别：

Acknowledgements. This study was supported by the grants from the National Nature Science Foundation of China (No. 81773293 and No. 81402536), Huxiang Youth Talent Program (2016RS3033) and the Science and Technology Plan Fund in Hunan Province, P.R. China (2014WK2016, 2013FJ6053, 2017JJ2410 and 2015JJ4083).

机构署名：

本校为通讯机构

院系归属：

食品科学与工程学院

摘要：

Colorectal cancer (CRC) is a most common digestive system malignant tumor. p53 mutation has essential role in cancers and is frequently observed in CRC and presents a huge challenge. p53 mutation has been reported to attenuate the inhibitory effect of photofrin-based photodynamic therapy (PDT). p53 mutation-induced gain of function brings up the dysfunction of carcinogenic factors, including miRNAs. Our research found that PDT suppressed CRC cell viability, reduced the tumor size and prolonged the survival time, all of which could be attenuated by p53 mutation or deletion. After p53 mutation o...

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Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line

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