Reducing sugar was made from cotton seed hull via synergistic hydrolysis with microwave and solid acid.The effects of microwave power, amount of solid acid, hydrolysis time, temperature and liquidsolid mass ratios on the reducing sugar yield were discussed. A quadratic regression model was founded with response surface methodology, and the process was optimized.The result showed that the reducing sugar yield was 62.49% as the microwave power was 461.91W, amaunt of solid acid was 6.46%, time was 2.99h, ...