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A new approach to replace antibiotics with natural pigment derivatives: Surface modification on the titanium implants

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成果类型:
期刊论文
作者:
Qu, Limin;Li, Xiangzhou;Li, Zhaoshuang;Zhou, Jun;Zheng, Min;...
通讯作者:
Li, Xiangzhou(RLXZ@163.com)
作者机构:
[Li, Zhaoshuang; Qu, Limin; Zhou, Jun; Shang, Yaxuan; Yang, Yanhong; Li, Xiangzhou; Zhou, Peng; Zheng, Min] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China.
[Li, Xiangzhou] Cent South Univ Forestry & Technol, Inst Nat Prod Res & Dev, Changsha 410004, Hunan, Peoples R China.
[Zheng, Min] Hunan First Normal Univ, Sch Phys & Chem, Changsha 410205, Hunan, Peoples R China.
[Wang, Wenlei] Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Xiangzhou Li] C
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, People’s Republic of China<&wdkj&>Institute of Natural Products Research and Development, Central South University of Forestry and Technology, Changsha, Hunan 410004, People’s Republic of China
语种:
英文
关键词:
Antibacterial;Antibiofilm;Curcumin;Molecular modification;Titanium implants
期刊:
Applied Surface Science
ISSN:
0169-4332
年:
2023
卷:
608
页码:
155122
基金类别:
This work was financially supported by the National Key R&D Program of China (Grant No. 2016YFD0600800 ).
机构署名:
本校为第一机构
院系归属:
材料科学与工程学院
理学院
摘要:
Bacterial infections associated with metal implants and devices are an urgent challenge in biomedical materials, especially when bacterial biofilms form on the implant surface. Here, we developed a novel strategy to combat infections with bacteria-associated titanium implants. Curcumin molecular modification was carried out on the phenolic hydroxyl group to obtain curcumin carboxylic acid (Cur-COOH) with the β-diketone structure of curcumin retained. Cur-COOH was covalently immobilized on the (3-aminopropyl) triethoxysilane (APTES)-treated tit...

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