Preparation, characterization and evaluation of cellulose nanocrystal/poly(lactic acid) in situ nanocomposite scaffolds for tissue engineering

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成果类型：

期刊论文

作者：

Luo, Weihua*;Cheng, Lianghao;Yuan, Caixia;Wu, Zhiping;Yuan, Guangming;...

通讯作者：

Luo, Weihua

作者机构：

[Luo, Weihua; Yuan, Guangming; Hou, Mingxi; Cheng, Lianghao; Wu, Zhiping; Yuan, Caixia] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China.

[Luo, Weihua; Yuan, Guangming; Wu, Zhiping] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Mat Surface & Interface Sci &, Changsha 410004, Hunan, Peoples R China.

[Luo, Weihua; Chen, Jonathan Y.] Univ Texas Austin, Sch Human Ecol, Austin, TX 78712 USA.

[Luo, Chunyi] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China.

[Li, Wei] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA.

通讯机构：

[Luo, Weihua] C

Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Cellulose nanocrystal;In situ nanocomposite;Scaffold;Tissue engineering

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2019

卷：

134

页码：

469-479

DOI：

10.1016/j.ijbiomac.2019.05.052

基金类别：

Major Program of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31890774]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31770606]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ2200]; China Scholarship CouncilChina Scholarship Council [201508430238]

机构署名：

本校为第一且通讯机构

院系归属：

材料科学与工程学院

摘要：

Cellulose nanocrystal (CNC)/poly(lactic acid) (PLA) in situ nanocomposite scaffolds were fabricated by in situ polymerization of lactic acid and CNC which was directly utilized as aqueous suspension, followed by a process of thermally induced phase separation. The CNC/PLA in situ nanocomposite porous scaffolds were characterized by mechanical test, protein adsorption, hemolysis test, in vitro degradation measurement, TEM, FTIR, SEM and WAXD. Compared to the PLA scaffold, the CNC/PLA in situ nanocomposite scaffolds showed a greatly increased compression modulus, an improved hemocompatibility an...

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Preparation, characterization and evaluation of cellulose nanocrystal/poly(lactic acid) in situ nanocomposite scaffolds for tissue engineering

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