Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling

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成果类型：

期刊论文

作者：

Liu, Bo;Yang, Tao;Luo, Yi;Zeng, Linna;Shi, Limin;...

通讯作者：

Lin, Qinlu;Luo, Feijun

作者机构：

[Liu, Bo; Zeng, Linna; Luo, Feijun; Yang, Tao; Cheng, Yu; Wei, Chengxi; Shi, Limin; Nie, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Lab Mol Nutr, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

[Liu, Bo; Zeng, Linna; Luo, Feijun; Cheng, Yu; Shi, Limin] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Coll Food Sci & Engn, Key Lab Special Med Food Proc Hunan Prov, Changsha 410004, Hunan, Peoples R China.

[Liu, Bo] Hunan Univ Chinese Med, Coll Pharm, Changsha 410004, Hunan, Peoples R China.

[Luo, Yi] Cent S Univ, Xiangya Sch Med, Coll Clin Med, Changsha 410008, Hunan, Peoples R China.

[Lin, Qinlu; Luo, FJ] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Lin, QL; Luo, FJ] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Oat beta-glucan;Hyperlipidemia;Steatosis;AMPK

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2018

卷：

页码：

72-82

DOI：

10.1016/j.jff.2017.12.045

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571874]; Collaborative Innovation Center of Hunan province [448]; Key Project of the Education Department of Hunan province [16A228]; Special Fund for Agro-scientific Research in the Public Interest of China [201303071-2-1]; Key Research and Develop Plan Project of Hunan Province [2017SK2190]; Hunan Key Laboratory for Processing of Special Medicine Food [2017TP1021]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

To evaluate the lowering-lipid effect of oat β-glucan (OβG) and its molecular mechanism, high-fat diet (HFD)-induced hyperlipidemic mouse model and oleic acid-induced lipid accumulation model of HepG2 cells were used in this study. OβG obviously reduced HFD-induced the gain of body weight and epididymal fat pad, and inhibited hepatic adipocyte hyperplasia. These effects were associated with the down-regulation of FAS and SREBP-1, up-regulation of PPARα and particularly the activation of AMP-activated protein kinase (AMPK) signaling in both ...

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Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling

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