Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling

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成果类型：

期刊论文

作者：

Liu, Bo;Yang, Tao;Luo, Yi;Zeng, Linna;Shi, Limin;...

通讯作者：

Lin, Qinlu;Luo, FJ

作者机构：

[Liu, Bo; Zeng, Linna; Luo, Feijun; Yang, Tao; Cheng, Yu; Wei, Chengxi; Shi, Limin; Nie, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Lab Mol Nutr, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

[Liu, Bo; Zeng, Linna; Luo, Feijun; Cheng, Yu; Shi, Limin] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Coll Food Sci & Engn, Key Lab Special Med Food Proc Hunan Prov, Changsha 410004, Hunan, Peoples R China.

[Liu, Bo] Hunan Univ Chinese Med, Coll Pharm, Changsha 410004, Hunan, Peoples R China.

[Luo, Yi] Cent S Univ, Xiangya Sch Med, Coll Clin Med, Changsha 410008, Hunan, Peoples R China.

[Luo, FJ; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Luo, FJ ; Lin, QL] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Oat beta-glucan;Hyperlipidemia;Steatosis;AMPK

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2018

卷：

页码：

72-82

DOI：

10.1016/j.jff.2017.12.045

基金类别：

This study was supported by National Natural Science Foundation of China (No. 31571874 ), “2011 Collaborative Innovation Center of Hunan province” (2013, No. 448), the Key Project of the Education Department of Hunan province (No. 16A228), the Special Fund for Agro-scientific Research in the Public Interest of China (No.201303071-2-1), The Key Research and Develop Plan Project of Hunan Province (2017SK2190) and Hunan Key Laboratory for Processing of Special Medicine Food (2017TP1021).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

To evaluate the lowering-lipid effect of oat β-glucan (OβG) and its molecular mechanism, high-fat diet (HFD)-induced hyperlipidemic mouse model and oleic acid-induced lipid accumulation model of HepG2 cells were used in this study. OβG obviously reduced HFD-induced the gain of body weight and epididymal fat pad, and inhibited hepatic adipocyte hyperplasia. These effects were associated with the down-regulation of FAS and SREBP-1, up-regulation of PPARα and particularly the activation of AMP-activated protein kinase (AMPK) signaling in both ...

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Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling

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