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Cyanidin-3-O-Glucoside Alleviates Alcoholic Liver Injury via Modulating Gut Microbiota and Metabolites in Mice

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成果类型:
期刊论文
作者:
Zhu, Lingfeng;Cao, Fuliang;Hu, Zuomin;Zhou, Yaping;Guo, Tianyi;...
通讯作者:
Luo, FJ
作者机构:
[Zhou, Yaping; Luo, Feijun; Lin, Qinlu; Zhu, Lingfeng; Yan, Sisi; Guo, Tianyi; Luo, FJ; Hu, Zuomin] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Changsha 410004, Peoples R China.
[Xie, Qiutao; Zhu, Lingfeng; Xia, Xinxin; Yuan, Hongyan] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.
[Cao, Fuliang] Nanjing Forestry Univ, Coll Forestry, Nanjing 210037, Peoples R China.
[Li, Gaoyang] Hunan Acad Agr Sci, Changsha 410125, Peoples R China.
通讯机构:
[Luo, FJ ] C
Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Changsha 410004, Peoples R China.
语种:
英文
关键词:
cyanidin-3-O-glucoside;alcoholic liver injury;gut microbiota;metabolomics
期刊:
Nutrients
ISSN:
2072-6643
年:
2024
卷:
16
期:
5
页码:
694-
基金类别:
Conceptualization, L.Z. and F.L.; methodology, L.Z., Z.H., Y.Z. and T.G.; validation, L.Z., Z.H., Y.Z. and T.G.; formal analysis, L.Z.; investigation, L.Z., Z.H., Y.Z., T.G., Q.X. and H.Y.; resources, F.C., Q.L. and F.L.; data curation, L.Z., Z.H., Y.Z., T.G., S.Y. and X.X.; writing—original draft preparation, L.Z.; writing—review and editing, F.L.; visualization, L.Z.; supervision, F.L; project administration, L.Z. and F.L.; funding acquisition, G.L. All authors have read and agreed to the published version of the manuscript. This study was financially supported by Hunan Province Modern Agricultural Industrial Technology System-Dry Grain Industrial Technology System project, Agricultural Science Technology Innovation Fund project of Hunan Province (2022CX27) and Changsha Natural Science Foundation project (kq2202333), Hunan Province, China.
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
Alcoholic liver disease (ALD) is primarily caused by long-term excessive alcohol consumption. Cyanidin-3-O-glucoside (C3G) is a widely occurring natural anthocyanin with multiple biological activities. This study aims to investigate the effects of C3G isolated from black rice on ALD and explore the potential mechanism. C57BL/6J mice (male) were fed with standard diet (CON) and Lieber-DeCarli liquid-fed (Eth) or supplemented with a 100 mg/kg/d C3G Diet (Eth-C3G), respectively. Our results showed that C3G could effectively ameliorate the pathological structure and liver function, and also inhibi...

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