Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

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成果类型：

期刊论文、会议论文

作者：

Wang, Xiao-Ling;Ding, Zhong-Yang;Liu, Gao-Qiang*;Yang, Hailong;Zhou, Guo-Ying

通讯作者：

Liu, Gao-Qiang

作者机构：

[Liu, Gao-Qiang; Zhou, Guo-Ying; Wang, Xiao-Ling] Cent South Univ Forestry & Technol, Minist Educ, Key Lab Cultivat & Protect Nonwood Forest Trees, Changsha 410004, Hunan, Peoples R China.

[Liu, Gao-Qiang; Zhou, Guo-Ying; Wang, Xiao-Ling] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Hunan Prov Key Lab Control Forest Dis & Pests, Changsha 410004, Hunan, Peoples R China.

[Ding, Zhong-Yang] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi 214122, Peoples R China.

[Yang, Hailong] Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China.

通讯机构：

[Liu, Gao-Qiang] C

Cent South Univ Forestry & Technol, Minist Educ, Key Lab Cultivat & Protect Nonwood Forest Trees, Changsha 410004, Hunan, Peoples R China.

Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Hunan Prov Key Lab Control Forest Dis & Pests, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

antineoplastic agent;ganoderic acid;ganoderic acid T;lanosterol;triterpene;analogs and derivatives;animal;bioreactor;cell proliferation;cell survival;chemistry;dose response;drug effects;drug screening;fermentation;Ganoderma;growth, development and aging;human;metabolism;microbiology;mouse;mycelium;sarcoma 180;tumor cell line;Animals;Antineoplastic Agents;Bioreactors;Cell Line, Tumor;Cell Proliferation;Cell Survival;Dose-Response Relationship, Drug;Fermentation;Ganoderma;Humans;Lanosterol;Mice;Mycelium;Sarcoma 180;Triterpenes;Xenograft Model Antitumor Assays

期刊：

Molecules

ISSN：

1420-3049

年：

2016

卷：

期：

页码：

1395

会议名称：

中国菌物学会2018年学术年会

会议论文集名称：

中国菌物学会2018年学术年会论文汇编

会议时间：

2018-08-11

会议地点：

中国山东泰安

DOI：

10.3390/molecules21101395

基金类别：

Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-13-1046]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ1025]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571900]

机构署名：

本校为第一且通讯机构

院系归属：

林学院

生命科学与技术学院

摘要：

Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G. lingzhi submerged culture mycelia possess antitumor activity needs to be further proven. In this study, enhanced TA yield and productivity were attained with G. lingzhi using response surface methodology. The interactions of three variables were studied using a Box-Benhnken design, namely initial pH, dissolved oxygen (DO) and...

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Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

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