Evaluation of the genotoxic and oxidative damage potential of silver nanoparticles in human NCM460 and HCT116 cells

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jia, Mingxi;Zhang, Wenjing;He, Taojin;Shu, Meng;Deng, Jing;...

通讯作者：

Li, Wen;Bai, Jie

作者机构：

[Luo, Feijun; Shu, Meng; Deng, Jing; Zhang, Wenjing; Li, Wen; Lin, Qinlu; Zhou, Wenhua; Li, W; Bai, Jie; Jia, Mingxi; He, Taojin] Cent South Univ Forestry & Technol, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Proc Food Special Med Purpose, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha 410004, Peoples R China.

[Deng, Jing; Zeng, Xiaoxi; Li, Wen; Jia, Mingxi] Hunan Univ Technol, Coll Life Sci & Chem, Key Lab Biol Nanomat & Devices, Zhuzhou 412007, Peoples R China.

[Wang, Jianhui] Changsha Univ Sci & Technol, Sch Chem & Food Engn, Changsha 410114, Peoples R China.

通讯机构：

[Li, W; Bai, J] C

[Li, Wen] H

Cent South Univ Forestry & Technol, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Proc Food Special Med Purpose, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha 410004, Peoples R China.

Hunan Univ Technol, Coll Life Sci & Chem, Key Lab Biol Nanomat & Devices, Zhuzhou 412007, Peoples R China.

语种：

英文

关键词：

complementary DNA;lactate dehydrogenase;messenger RNA;protein Bax;protein bcl 2;protein p21;protein p53;reactive oxygen metabolite;silver nanoparticle;antiinfective agent;BAX protein, human;BCL2 protein, human;CDKN1A protein, human;cyclin dependent kinase inhibitor 1A;metal nanoparticle;mitogen activated protein kinase p38;protein Bax;protein bcl 2;protein p53;silver;TP53 protein, human;apoptosis;Article;cell proliferation;colon cancer cell line;controlled study;crystal structure;cytotoxicity;down regulation;flow cytometry;gene expression;genotoxicity;HCT 116 cell line;mRNA expression level;MTT assay;NCM460 cell line;optical density;oxidative stress;particle size;protein expression;protein phosphorylation;reverse transcription polymerase chain reaction;RNA isolation;transmission electron microscopy;upregulation;Western blotting;X ray diffraction;cell survival;chemistry;cytology;DNA damage;drug effect;epithelium cell;genetics;human;metabolism;oxidative stress;phosphorylation;ultrastructure;Anti-Bacterial Agents;bcl-2-Associated X Protein;Cell Survival;Cyclin-Dependent Kinase Inhibitor p21;DNA Damage;Epithelial Cells;HCT116 Cells;Humans;Metal Nanoparticles;Microscopy, Electron, Transmission;Oxidative Stress;p38 Mitogen-Activated Protein Kinases;Phosphorylation;Proto-Oncogene Proteins c-bcl-2;Reactive Oxygen Species;Silver;Tumor Suppressor Protein p53

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2020

卷：

期：

页码：

1618

DOI：

10.3390/ijms21051618

基金类别：

Funding: This research was funded by the National Key R&D Program of China (2018YFE0110200 and 2015BAD05B02), the National Natural Science Foundation of China (51774128), the Natural Science Foundation of Hunan Province of China (2018JJ4061, 2018JJ2672, 2018JJ2090 and 2018JJ4009), the key program of Hunan Provincial Department of science and technology (2016NK2096, 2019NK2111 and 2019SK2121), Program for Science & Technology Innovation Talents of Hunan Province (2017TP1021, kc1704007), the Hunan Scientific Talents Promotion Program of Hunan Association for Science and Technology (2019TJ‐Q01), the Scientific Research Fund of Hunan Provincial Education Department (17A055 and 18B290) and the Zhuzhou Key Science & Technology Program of Hunan Province (2017, 2018 and 2019). This research was funded by the National Key R&D Program of China (2018YFE0110200 and 2015BAD05B02), the National Natural Science Foundation of China (51774128), the Natural Science Foundation of Hunan Province of China (2018JJ4061, 2018JJ2672, 2018JJ2090 and 2018JJ4009), the key program of Hunan Provincial Department of science and technology (2016NK2096, 2019NK2111 and 2019SK2121), Program for Science & Technology Innovation Talents of Hunan Province (2017TP1021, kc1704007), the Hunan Scientific Talents Promotion Program of Hunan Association for Science and Technology (2019TJ?Q01), the Scientific Research Fund of Hunan Provincial Education Department (17A055 and 18B290) and the Zhuzhou Key Science & Technology Program of Hunan Province (2017, 2018 and 2019).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Nano Ag has excellent antibacterial properties and is widely used in various antibacterial materials, such as antibacterial medicine and medical devices, food packaging materials and antibacterial textiles. Despite the many benefits of nano‐Ag, more and more research indicates that it may have potential biotoxic effects. Studies have shown that people who ingest nanoparticles by mouth have the highest uptake in the intestinal tract, and that the colon area is the most vulnerable to damage and causes the disease. In this study, we examined the ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Evaluation of the genotoxic and oxidative damage potential of silver nanoparticles in human NCM460 and HCT116 cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问