INTRODUCTION: Predicting the relationship between diseases and microbes can significantly enhance disease diagnosis and treatment, while providing crucial scientific support for public health, ecological health, and drug development. METHODS: In this manuscript, we introduce an innovative computational model named BANSMDA, which integrates Bilinear Attention Networks with sparse autoencoder to uncover hidden connections between microbes and diseases. In BANSMDA, we first constructed a heterogeneous microbe-disease network by integrating multiple Gaussian similarity measures for diseases and mi...