Poly (Thioether-Polyesters) Micelles Encapsulation Induces ROS-Triggered Targeted Release of Tangeretin

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成果类型：

期刊论文

作者：

Tan, Bozhan;Qi, Zhiwen;Yang, Guliang;Zhong, Haiyan

通讯作者：

Zhong, HY;Qi, ZW

作者机构：

[Yang, Guliang; Zhong, Haiyan; Tan, Bozhan; Zhong, HY] Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & Prod Proc, Changsha 410004, Hunan, Peoples R China.

[Tan, Bozhan] Hunan Changkang Ind Co LTD, Yueyang, Hunan, Peoples R China.

[Qi, ZW; Qi, Zhiwen] Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China.

通讯机构：

[Qi, ZW ; Zhong, HY ] C

Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & Prod Proc, Changsha 410004, Hunan, Peoples R China.

Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China.

语种：

英文

关键词：

hydrogen peroxide;inducible nitric oxide synthase;interleukin 6;lipopolysaccharide;phosphate buffered saline;phosphatidylinositol 3 kinase;polyester;polymer;prodrug;protein kinase B;reactive oxygen metabolite;sodium chloride;tangeretin;tumor necrosis factor;animal cell;antiinflammatory activity;antioxidant activity;Article;cell viability;controlled study;dispersity;drug bioavailability;drug cytotoxicity;drug formulation;drug release;drug solubility;drug stability;encapsulation;ex vivo study;Fourier transform infrared spectroscopy;high performance liquid chromatography;hydrophilicity;hydrophobicity;in vitro study;in vivo study;infrared radiation;macrophage;micelle;mouse;nonhuman;particle size;pH;Pi3K/Akt signaling;protein expression level;proton nuclear magnetic resonance;radiation absorption;RAW 264.7 cell line;water solubility;zeta potential

期刊：

Natural Product Communications

ISSN：

1934-578X

年：

2022

卷：

期：

页码：

1934578X2210803

DOI：

10.1177/1934578X221080335

基金类别：

This study was supported by the key scientific research projects of Natural Science Foundation of Hunan Province (No. 2021JJ31154) and the National Nonprofit Institute Research Grant of CAFINT, China (No. CAFYBB2018GA001).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Tangeretin (Tan) possesses great anti-oxidation and anti-inflammation bioactivities; however, it is accompanied by poor water solubility, which leads to inefficient cellular internalization. To address this issue, a reactive oxygen species (ROS)-triggered poly (thioether-polyesters) micelle (PDHP, PEG-DTT) was designed and prepared via self-assembly, which consisted of poly (thioether-polyesters) as the hydrophilic shell, and the drug Tan as the hydrophobic inner core. The micelles (Tan@ PDHP), with a 63.15% loading efficiency of Tan, showed ne...

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Poly (Thioether-Polyesters) Micelles Encapsulation Induces ROS-Triggered Targeted Release of Tangeretin

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