Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor alpha

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成果类型：

期刊论文

作者：

Zhou, Qian;Zhang, Lei;Chen, Zibo;Zhao, Pingge;Ma, Yaxi;...

通讯作者：

Ying, Meidan

作者机构：

[Zhou, Qian; Yang, Bo; He, Qiaojun; Ying, Meidan; Zhang, Lei] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Inst Pharmacol & Toxicol, Hangzhou 310003, Zhejiang, Peoples R China.

[Chen, Zibo] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha, Hunan, Peoples R China.

[Zhao, Pingge] Yiwu Cent Hosp, Dept Clin Pharm, Yiwu, Peoples R China.

[Ma, Yaxi] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gynecol, Hangzhou 310003, Zhejiang, Peoples R China.

[Ying, Meidan] Zhejiang Univ, Bldg Coll Pharmaceut Sci, Room 109,Zijingang Campus, Hangzhou 310058, Zhejiang, Peoples R China.

通讯机构：

[Ying, Meidan] Z

Zhejiang Univ, Bldg Coll Pharmaceut Sci, Room 109,Zijingang Campus, Hangzhou 310058, Zhejiang, Peoples R China.

语种：

英文

关键词：

SUMOylation;differentiation;retinoic acid;retinoic acid receptor alpha;small ubiquitin-related modifier-1

期刊：

FEBS JOURNAL

ISSN：

1742-464X

年：

2014

卷：

281

期：

页码：

3032-3047

DOI：

10.1111/febs.12840

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202558]; Zhejiang Provincial Program for Qianjiang Talents [2013R10025]; Health Bureau of Zhejiang Province [2013KYA055]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY12H31005, LY12H16012]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Program for Zhejiang Leading Team of S&T Innovation and Science Technology Department of Zhejiang Province [2013C33104]

机构署名：

本校为其他机构

院系归属：

材料科学与工程学院

摘要：

Small ubiquitin‐related modifier‐1 (SUMO‐1) modification has been implicated in many important cellular processes, including cell cycle progression, apoptosis, cellular proliferation, and development, but its role in all‐trans‐retinoic acid (ATRA)‐induced differentiation processes of cancer cells remains unclear. Here, we report for the first time that ATRA‐induced differentiation of leukemia and osteosarcoma is accompanied by a decrease in the level of SUMO‐1 protein. Our results also demonstrated that depletion or inhibition of SUMO‐...

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Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor alpha

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