H-NS involved in positive regulation of glycerol dehydratase gene expression in Klebsiella pneumoniae 2e

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成果类型：

期刊论文

作者：

Li, Le;Li, Qiang;Xiao, Yuting;Ma, Jiangshan*;Liu, Gao-Qiang

通讯作者：

Ma, Jiangshan;Liu, GQ

作者机构：

[Liu, GQ; Li, Qiang; Ma, Jiangshan; Xiao, Yuting; Li, Le; Liu, Gao-Qiang] Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Res, Changsha, Peoples R China.

[Liu, GQ; Li, Qiang; Ma, Jiangshan; Xiao, Yuting; Li, Le; Liu, Gao-Qiang] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha, Peoples R China.

[Liu, GQ; Li, Qiang; Ma, Jiangshan; Xiao, Yuting; Li, Le; Liu, Gao-Qiang] Yuelushan Natl Lab Seed Ind, Econ Forest Variety Creat Ctr, Changsha, Peoples R China.

通讯机构：

[Liu, GQ ; Ma, JS] C

Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Res, Changsha, Peoples R China.

Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha, Peoples R China.

Yuelushan Natl Lab Seed Ind, Econ Forest Variety Creat Ctr, Changsha, Peoples R China.

语种：

英文

关键词：

glycerol dehydratase;expression regulation mechanism;H-NS;Klebsiella pneumoniae;oligomerization state

期刊：

Applied and Environmental Microbiology

ISSN：

0099-2240

年：

2024

卷：

期：

页码：

e0007524

DOI：

10.1128/aem.00075-24

基金类别：

MOST | National Natural Science Foundation of China (NSFC) [31900087, 32071673]; National Natural Science Foundation of China [2022RC1153]; Science and Technology Innovation Program of Hunan Province [23A0214]; Key Scientific Research Project of Hunan Provincial Education Department [2020JJ5974]; Natural Science Foundation of Hunan Province [2021RC4063]; Program of Hunan Science and Technology Innovation Team

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

摘要：

Glycerol dehydratase is the key and rate-limiting enzyme in the 1,3-propanediol synthesis pathway of Klebsiella pneumoniae, which determined the producing rate and yield of 1,3-propanediol. However, the expression regulation mechanism of glycerol dehydratase gene dhaB remains poorly unknown. In this study, a histone-like nucleoid-structuring (H-NS) protein was identified and characterized as the positive transcription regulator for dhaB expression in K. pneumoniae 2e, which exhibited high tolerance against crude glycerol in our previous study. Deletion of hns gene significantly decreased the t...

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H-NS involved in positive regulation of glycerol dehydratase gene expression in Klebsiella pneumoniae 2e

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