期刊论文

Lin, Qinlu;Liu, Gao-Qiang

英文

International Journal of Biological Macromolecules

0141-8130

2016

89

456-464

10.1016/j.ijbiomac.2016.04.037

Program for New Century Excellent Talents in University, Ministry of EducationProgram for New Century Excellent Talents in University (NCET) [NCET-13-1046]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ1025]; Hunan Provincial S&T Plan Key Project of China [2013WK4006]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571874]; Scientific Research Project of Hunan Provincial Education Department [YB20158032]; Hunan Provincial Grain-oil Process and Quality Control Collaborative and Innovative Grant from Hunan Province [[2013] 448]

本校为第一机构

In this study, we developed a new nanoparticulate system for acetylated starch nanocrystals (ASN) using broken rice. ASN with different degrees of substitution (DS) of 0.04, 0.08 and 0.14 were prepared using acetic anhydride as acetylating agent through reaction with starch nanocrystals (SN). The resulting ASN were investigated for the capability to load and release doxorubicin hydrochloride (DOX), and the antitumor activities of DOX-loaded SN and DOX-loaded ASN were evaluated as potential drug delivery systems for cancer therapy. Cellular uptake and cytotoxicity of nanocrystals and the DOX-lo...