期刊论文

中文

北京体育大学学报

1007-3612

2011

34

2

55-60

10.19582/j.cnki.11-3785/g8.2011.02.015

湖南省卫生厅科研基金

本校为第一机构

目的：从p38 MAPK信号转导通路的角度探讨运动降低糖尿病血糖水平的机制,为运动治疗糖尿病提供科学依据和参考。研究方法：雄性6月龄KK-Ay和C57BL/6J小鼠各12只,按血糖配对后随机分为糖尿病运动组（KE组）和糖尿病对照组（KC组）;正常运动组（CE组）和正常对照组（CC组）。进行坡度0°,速度12 m/min,时间30 min的跑台运动后,实验检测p38蛋白表达和磷酸化,测定血糖浓度、血清胰岛素和TNF-α、FFA。研究结果：KK-Ay小鼠血糖高于C57BL/6J小鼠,KE组和CE组血糖分别较实验前下降了34%和25%;运动后CE组血清胰岛素浓度比CC组低55%,KE组则较KC组低43%;骨骼肌p38磷酸化水平KC组高于CC组,CE组高于C组,KE组高...

Purpose：This study is to discuss possible mechanism of glucose-lowering through exercise from p38MAPK pathways and then provides the scientific basis and the reference for curing diabetes by exercise.Mouses：12 six-month-old male KK-Ay mouses and 12 C57BL/6J mouses were divided into four groups randomly according to the blood sugar： diabetes exercise group（KE group） and diabetes control group（KC group）;normal exercise group（CE group） and normal control group （CC group）.The experiment was carried out on a flat surface with zero degree ...