Cyclophilins （CyPs） are supper-family members and ubiquitously distributed in vertebrates, invertebrates, other metazoa, plants, fungi, and prokaryotes, and present in endoplasmic reticulum, Gologi apparatus, mitochondion, chloroplas and cytosol, et al. They are highly conservative, possessing peptidyl-prolyl cis-trans isomerase activity, and are also involved in a wide variety of processes including immunodepression activity, protein folding and cell signaling. The structures of plant CyPs. containing differently 7 unique, positively charged...
