An ICT-based mitochondrial binding enhanced fluorescent probe for measurement of monoamine oxidase A in living cells

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成果类型：

期刊论文

作者：

Chen, Daian;Guo, Zhen;Hu, Yingcai;Deng, Ting*;Li, Jishan*

通讯作者：

Deng, Ting;Li, Jishan

作者机构：

[Guo, Zhen; Chen, Daian] Institute of Applied Chemistry, College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China

[Hu, Yingcai; Chen, Daian] State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

[Deng, Ting] Institute of Applied Chemistry, College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China. Electronic address: muzi_dt@hotmail.com

[Li, Jishan] State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. Electronic address: jishanli@hnu.edu.cn

通讯机构：

[Li, Jishan] S

[Deng, Ting] I

Institute of Applied Chemistry, College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China. Electronic address:

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. Electronic address:

语种：

英文

关键词：

Fluorescence imaging assay;Intramolecular charge transfer (ICT);Living cells;Mitochondrial binding enhanced fluorescent probe;Monoamine oxidase A (MAO-A)

期刊：

Talanta

ISSN：

0039-9140

年：

2026

卷：

298

期：

Pt A

页码：

128896

DOI：

10.1016/j.talanta.2025.128896

基金类别：

CRediT authorship contribution statement Daian Chen: Writing – original draft, Investigation, Formal analysis, Data curation. Zhen Guo: Investigation, Data curation. Yingcai Hu: Investigation, Formal analysis. Ting Deng: Writing – review & editing, Supervision, Resources, Formal analysis, Conceptualization. Jishan Li: Writing – review & editing, Project administration, acquisition, Conceptualization.

机构署名：

本校为第一且通讯机构

院系归属：

理学院

摘要：

In this study, we developed an intramolecular charge transfer (ICT)-based fluorescent probe (TPA-S-P), which features a donor-π-acceptor push-pull architecture, in which the donor triphenylamine (TPA) moiety was conjugated to the 1-methyltetrahydropyridine (P) acceptor moiety through a thiophene (S) bridge. In the presence of Monoamine Oxidase A (MAO-A), the P acceptor moiety was oxidized to a positively charged methylpyridinium moiety (Ps), which was capable of binding to the negatively charged mitochondrial membrane, resulting in significant...

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An ICT-based mitochondrial binding enhanced fluorescent probe for measurement of monoamine oxidase A in living cells

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