Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

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成果类型：

期刊论文

作者：

Hu, Tao;Lin, Qinlu;Guo, Ting;Yang, Tao;Zhou, Wenhua;...

通讯作者：

Yan, Jing-Kun;Luo, Feijun

作者机构：

[Ju, Mengmeng; Hu, Tao; Zhou, Wenhua; Luo, Feijun; Guo, Ting; Yang, Tao; Deng, Xiaofan; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Proc Food Special Med Purpose,Natl, Changsha 41004, Hunan, Peoples R China.

[Yan, Jing-Kun] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.

[Luo, Yi] Cent S Univ, Xiangya Sch Med, Dept Clin Med, Changsha 410008, Hunan, Peoples R China.

[Luo, Feijun] Cent South Univ Forestry & Technol, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Yan, Jing-Kun] J

[Luo, Feijun] C

Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.

Cent South Univ Forestry & Technol, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

AP-1;Colitis;Inflammation;MAPK;NF-kappaB;PPAR;Phellinus linteuspolysaccharide (PLP)

期刊：

Carbohydrate Polymers

ISSN：

0144-8617

年：

2018

卷：

200

页码：

487-497

DOI：

10.1016/j.carbpol.2018.08.021

基金类别：

This research was financially supportedby Natural Science Foundation of Hunan Province [No. 2018JJ2672], “2011Collaborative Innovation Center” of Hunan province [2013, No. 448], the Key Project of the Education Department of Hunan province [No. 16A228], the Special Fund for Agro-scientific Research in the Public Interest of China [No. 201303071-2-1], The Key Research and Develop Plan Project of Hunan Province [2017SK2190] and Science and Technology Innovation Platform and Talent Project of Hunan Province [2017TP1021].

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

In the present study, the anti-inflammatory function of Phellinus linteus polysaccharide (PLP) was investigated in animal and cell inflammation models, and the anti-inflammatory mechanism of PLP was also explored. Sixty 8-week ICR mice were randomly divided into 3 groups, and DSS group and DSS + PLP group mice received 2.0% DSS and PLP was orally administered at 500 mg/kg/day. Our data showed that PLP administration obviously improved the health status of mice and inhibited DSS-induced pathological alterations and significantly reduced inflamma...

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Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways

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