Octacosanol Attenuates Inflammation in Both RAW264.7 Macrophages and a Mouse Model of Colitis

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成果类型：

期刊论文

作者：

Guo, Tianyi;Lin, Qinlu;Li, Xinhua;Nie, Ying;Wang, Long;...

通讯作者：

Luo, Feijun

作者机构：

[Wang, Long; Hu, Tao; Luo, Feijun; Guo, Ting; Guo, Tianyi; Shi, Limin; Nie, Ying; Xu, Wei; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & Byprod, Lab Mol Nutr, Changsha 410004, Hunan, Peoples R China.

[Li, Xinhua] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China.

[Luo, Feijun] Cent South Univ Forestry & Technol, Coll Food Sci & Technol, Lab Mol Nutr, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Luo, Feijun] C

Cent South Univ Forestry & Technol, Coll Food Sci & Technol, Lab Mol Nutr, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

octacosanol;colitis;inflammation factor;MAPK;NF-kappa B;AP-1

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2017

卷：

期：

页码：

3647-3658

DOI：

10.1021/acs.jafc.6b05465

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571874]; Project "The Grain-oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province" [448]; Key Project of the Education Department of Hunan province [16A228, 13A124]; Graduate Innovative Research Project of Hunan province; Central South University of Forestry and Technology [CX2016B23, CX2016B334]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Octacosanol has multiple biological functions. In this study, the anti-inflammatory effect and molecular mechanism of octacosanol were evaluated by using dextran sulfate sodium (DSS)-induced ulcerative colitis model in mice and lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells. The colitis mouse model was induced by 3.0% DSS in 8-week ICR mice and octacosanol orally administered with 100 mg/kg/day. The results showed that octacosanol significantly improved the health status of mice and reduced DSS-induced pathological damage in the colonic tissues. Octacosanol obviously inhib...

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Octacosanol Attenuates Inflammation in Both RAW264.7 Macrophages and a Mouse Model of Colitis

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