δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shen, Junjun;Yang, Tao;Xu, Youzhi;Luo, Yi;Zhong, Xinyue;...

通讯作者：

Luo, Feijun;Lin, Qinlu

作者机构：

[Hu, Tao; Luo, Feijun; Yang, Tao; Guo, Tianyi; Zhong, Xinyue; Shi, Limin; Luo, FJ; Lin, Qinlu; Shen, Junjun; Nie, Ying; Xu, Youzhi] Cent South Univ Forestry & Technol, Hunan Key Lab Proc Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha 410004, Hunan, Peoples R China.

[Luo, Yi] Cent S Univ, Xiangya Sch Med, Dept Clin Med, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Luo, FJ; Lin, QL] C

Cent South Univ Forestry & Technol, Hunan Key Lab Proc Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

alpha tocopherol;antiinflammatory agent;cytokine;immunoglobulin enhancer binding protein;lipopolysaccharide;mitogen activated protein kinase 1;mitogen activated protein kinase 3;mitogen activated protein kinase kinase 4;nitric oxide;peroxisome proliferator activated receptor;tocotrienol, delta;analogs and derivatives;animal;cell line;chemistry;drug effect;macrophage;MAPK signaling;metabolism;mouse;Oryza;Animals;Anti-Inflammatory Agents;Cell Line;Cytokines;Lipopolysaccharides;Macrophages;MAP Kinase Kinase 4;MAP Kinase Signaling System;Mice;Mitogen-Activated Protein Kinase 1;Mitogen-Activated Protein Kinase 3;NF-kappa B;Nitric Oxide;Oryza;Peroxisome Proliferator-Activated Receptors;Vitamin E

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2018

卷：

期：

页码：

3022

DOI：

10.3390/ijms19103022

基金类别：

This study was supported by the Project “2011 Collaborative Innovation Center of Hunan province” (2013, No. 448), Natural Science Foundation of Hunan Province (No.2018JJ2672, No.2017JJ3528), the Key Project of the Education Department of Hunan province (No. 16A228), the Special Fund for Agro-scientific Research in the Public Interest of China (No.201303071-2-1), The Key Research and Develop Plan Project of Hunan Province (2017SK2190) and Science and Technology Innovation Platform and Talent Project of Hunan Province (2017TP1021). Funding: This study was supported by the Project “2011 Collaborative Innovation Center of Hunan province” (2013, No. 448), Natural Science Foundation of Hunan Province (No.2018JJ2672, No.2017JJ3528), the Key Project of the Education Department of Hunan province (No. 16A228), the Special Fund for Agro-scientific Research in the Public Interest of China (No.201303071-2-1), The Key Research and Develop Plan Project of Hunan Province (2017SK2190) and Science and Technology Innovation Platform and Talent Project of Hunan Province (2017TP1021).

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of δ-tocotrienol against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264.7 cells were investigated. Results showed that δ-tocotrienol significantly inhibited LPS-stimulated nitric oxide (NO) an...

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δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages

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