-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shen, Junjun;Yang, Tao;Xu, Youzhi;Luo, Yi;Zhong, Xinyue;...

通讯作者：

Luo, Feijun;Lin, Qinlu

作者机构：

[Hu, Tao; Luo, Feijun; Yang, Tao; Guo, Tianyi; Zhong, Xinyue; Shi, Limin; Luo, FJ; Lin, Qinlu; Shen, Junjun; Nie, Ying; Xu, Youzhi] Cent South Univ Forestry & Technol, Hunan Key Lab Proc Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha 410004, Hunan, Peoples R China.

[Luo, Yi] Cent S Univ, Xiangya Sch Med, Dept Clin Med, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Luo, FJ; Lin, QL] C

Cent South Univ Forestry & Technol, Hunan Key Lab Proc Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Inflammation;Mapks;Ppars;Raw264.7;Rice bran;δ-tocotrienol

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2018

卷：

期：

DOI：

10.3390/ijms19103022

基金类别：

Project "2011 Collaborative Innovation Center of Hunan province" [448]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ2672, 2017JJ3528]; Key Project of the Education Department of Hunan province [16A228]; Special Fund for Agro-scientific Research in the Public Interest of China [201303071-2-1]; Key Research and Develop Plan Project of Hunan Province [2017SK2190]; Science and Technology Innovation Platform and Talent Project of Hunan Province [2017TP1021]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of δ-tocotrienol against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264.7 cells were investigated. Results showed that δ-tocotrienol significantly inhibited LPS-stimulated nitric oxide (NO) an...

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-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages

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