Elastic modulus and migration capability of drug treated leukemia cells K562

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Kui;Xue, Yuntian;Peng, Ying;Pang, Xiangchao;Zhang, Yuanjun;...

通讯作者：

Tang, Bin

作者机构：

[Peng, Ying; Zhang, Yuanjun; Xue, Yuntian; Ruiz-Ortega, L. I.; Wang, Kui; Tian, Ye; Tang, Bin] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China.

[Ngan, A. H. W.; Wang, Kui] Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China.

[Tang, Bin] Shenzhen Key Lab Cell Microenvironm, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen, Peoples R China.

[Pang, Xiangchao] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Tang, Bin] S

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

Leukemia cells;Optical tweezers;PMA;Stiffness;Vimentin

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2019

卷：

516

期：

页码：

177-182

DOI：

10.1016/j.bbrc.2019.06.024

基金类别：

This study is financially supported by National Natural Science Foundation of China (Project No. 11872200), Guangdong Foundation of Science and Technology (Project No. 2017B030301018), Shenzhen Science and Technology Innovation Committee (Project No. JCYJ20160517160827379, JCYJ20170817111312887 and ZDSYS20140509142721429).

机构署名：

本校为其他机构

院系归属：

材料科学与工程学院

摘要：

Leukemia is a commonly seen disease caused by abnormal differentiation of hematopoietic stem cells and blasting in bone marrow. Despite drugs are used to treat the disease clinically, the influence of these drugs on leukemia cells’ biomechanical properties, which are closely related to complications like leukostasis or infiltration, is still unclear. Due to non-adherent and viscoelastic nature of leukemia cells, accurate measurement of their elastic modulus is still a challenging issue. In this study, we adopted rate-jump method together with ...

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Elastic modulus and migration capability of drug treated leukemia cells K562

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