Fatty acid metabolization and insulin regulation prevent liver injury from lipid accumulation in Himalayan marmots

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成果类型：

期刊论文

作者：

Bao, Ziqiang;Guo, Cheng;Chen, Yi;Li, Cheng;Lei, Tao;...

通讯作者：

Xiang, ZF

作者机构：

[Guo, Cheng; Li, Cheng; Bao, Ziqiang; Zhou, Shuailing; Lei, Tao] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Changsha 410004, Hunan, Peoples R China.

[Chen, Yi; Guo, Cheng; Bao, Ziqiang; Xiang, Zuofu] Cent South Univ Forestry & Technol, Inst Evolutionary Ecol & Conservat Biol, Changsha 410004, Hunan, Peoples R China.

[Chen, Yi; Xiang, Zuofu] Cent South Univ Forestry & Technol, Coll Forestry, Changsha 410004, Hunan, Peoples R China.

[Li, Cheng; Qi, Dunwu] Chengdu Res Base Giant Panda Breeding, Chengdu 610081, Sichuan, Peoples R China.

[Xiang, Zuofu] Carbon Sinks Forests Variety Innovat Ctr, Yuelushan Lab, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Xiang, ZF ] C

Cent South Univ Forestry & Technol, Inst Evolutionary Ecol & Conservat Biol, Changsha 410004, Hunan, Peoples R China.

Cent South Univ Forestry & Technol, Coll Forestry, Changsha 410004, Hunan, Peoples R China.

Carbon Sinks Forests Variety Innovat Ctr, Yuelushan Lab, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

CP: Metabolism;Himalayan marmots;dietary change;fat storage;fatty acid;gut microbiome;hibernation;insulin;lipid metabolism;liver protection mechanism;weight gain

期刊：

Cell Reports

ISSN：

2211-1247

年：

2023

卷：

期：

页码：

112718

DOI：

10.1016/j.celrep.2023.112718

基金类别：

National Natural Science Foundation of China [32171487]; State Forestry and Grassland Administration Bureau of China [2019076079]; postdoctoral research grants at the Central South University of Forestry and Technology [45220003]

机构署名：

本校为第一且通讯机构

院系归属：

林学院

生命科学与技术学院

摘要：

Fat storage and weight gain are dominant traits for hibernating mammals. However, excessive fat accumulation may cause liver damage. Here, we explore the lipid accumulation and metabolic processes of the Himalayan marmot (Marmota himalayana), a hibernating rodent species. We find that the unsaturated fatty acid (UFA) content in food was consistent with a large increase in the body mass of Himalayan marmots. Metagenomic analysis shows that Firmicutes Bacterium CAG:110 plays a synergistic role by synthesizing UFAs, which is demonstrated by fecal transplantation experiments, indicating that the g...

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Fatty acid metabolization and insulin regulation prevent liver injury from lipid accumulation in Himalayan marmots

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