Polymorphism of neurodegeneration-related genes associated with Parkinson\'s disease risk - 成果

Polymorphism of neurodegeneration-related genes associated with Parkinson's disease risk

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Jiaxin;Yi, Minhan;Li, Binbin;Yin, Shujuan;Zhang, Ying;...

通讯作者：

Zhang, Y

作者机构：

[Yi, Minhan; Li, Binbin; Zhang, Yuan; Li, Jiaxin] Cent South Univ, Xiangya Hosp, Dept Resp Med, Changsha, Hunan, Peoples R China.

[Yi, Minhan; Li, Binbin; Zhang, Yuan; Li, Jiaxin] Xiangya Hosp, Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.

[Yin, Shujuan; Li, Binbin; Li, Jiaxin] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China.

[Yi, Minhan] Cent South Univ, Sch Life Sci, Changsha, Hunan, Peoples R China.

[Zhang, Ying] Xiangya Hosp, Teaching & Res Sect Clin Nursing, Cent South Univ, Changsha, Peoples R China.

通讯机构：

[Zhang, Y ]

Cent South Univ, Xiangya Hosp, Dept Resp Med, Changsha, Hunan, Peoples R China.

Xiangya Hosp, Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Parkinson's disease;Genetics;Polymorphism;Dopamine;Neurodegeneration

期刊：

Neurological Sciences

ISSN：

1590-1874

年：

2022

卷：

期：

页码：

5301-5312

DOI：

10.1007/s10072-022-06192-8

基金类别：

National Natural Science Foundation of China [82001357]; Hunan Provincial Natural Science Foundation of China [2020JJ5951, 2021JJ80079]; Youth Science Foundation of Xiangya Hospital [2019Q17]; Degree & Postgraduate Education Reform Project of Central South University [2021YJSKSA10]; Undergraduate Education Reform Project of Central South University [2021CG065, 2021CG068]; Research Project of Laboratory Construction and Management of Central South University [202120]

机构署名：

本校为其他机构

院系归属：

班戈学院

摘要：

Background: Neurodegenerative genes are critical in neuronal loss in Parkinson’s disease (PD). We performed a systematic meta-analysis including all the studies published on PD risk related to genes encoding enzymes vital for dopamine metabolism and neuron survival. Methods: We included neurodegeneration-related genes which were divided into four groups according to their functions: main enzymes in dopamine metabolism, receptors and transporters for dopamine or other metabolites, neuroprotective factors for dopaminergic neurons, and genes asso...

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Polymorphism of neurodegeneration-related genes associated with Parkinson's disease risk

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