Graphene thin films are often used to manufacture various optoelectronic nanodevices owing to their advantages such as light weight, small size, high quality factor, and good conductivity. So far, there have been few studies of the four-wave mixing characteristics in a bilayer graphene nanosystem, especially theoretical research. In this work, we study theoretically the four-wave mixing properties in a bilayer graphene nanosystem. Firstly, the analytical formula of the four-wave mixing signal is derived by quantum mechanical method, which is divided into three steps. 1) Total Hamiltonian of th...