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Spongian diterpenes from Chinese marine sponge Spongia officinalis

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成果类型:
期刊论文
作者:
Han, Guan-Ying;Sun, Dong-Yu;Liang, Lin-Fu*;Yao, Li-Gong;Chen, Kai-Xian;Guo, Yue-Wei*
通讯作者:
Liang, Lin-Fu;Guo, Yue-Wei
作者机构:
[Han, Guan-Ying; Sun, Dong-Yu; Guo, Yue-Wei; Chen, Kai-Xian; Liang, Lin-Fu; Yao, Li-Gong] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China
[Han, Guan-Ying] The First Affiliated Hospital of Jinzhou Medical University, 2 Renmin Road, Jinzhou 121001, China
[Sun, Dong-Yu] School of Pharmaceutical Sciences, Jinzhou Medical University, Jinzhou 121001, China
[Guo, Yue-Wei] Open Studio for Drugability Research of Marine Natural Products, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address: ywguo@simm.ac.cn
[Chen, Kai-Xian] Open Studio for Drugability Research of Marine Natural Products, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China
通讯机构:
[Liang, Lin-Fu] College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China. Electronic address:
[Guo, Yue-Wei] Open Studio for Drugability Research of Marine Natural Products, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address:
语种:
英文
关键词:
Spongia officinalis;Diterpene;3-Nor-spongian;Absolute configuration
期刊:
Fitoterapia
ISSN:
0367-326X
年:
2018
卷:
127
页码:
159-165
文献类别:
WOS:Article
所属学科:
ESI学科类别:药理学&毒理学;WOS学科类别:Chemistry, Medicinal;Pharmacology & Pharmacy
入藏号:
WOS:000437551000024;PMID:29447982
基金类别:
Natural Science Foundation of China [81520108028, 41476063, 41506187]; NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]; STCSM [15431901000]; SKLDR/SIMM [SIMM1705ZZ-01]
机构署名:
本校为通讯机构
院系归属:
材料科学与工程学院
摘要:
3-Nor-spongiolide A (1), belonging to the extremely rare 3-nor-spongian carbon skeleton, and spongiolides A (2) and B (3), having gamma-butenolide instead of furan ring as usual for ring D, together with six related known metabolites were isolated from South China Sea sponge Spongia officinalis as its metabolic components. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of three new compounds 1-3 were determined by ECD calculations.
参考文献:
Bruhn T, 2013, CHIRALITY, V25, P243, DOI 10.1002/chir.22138
CAMBIE RC, 1988, J NAT PROD, V51, P293, DOI 10.1021/np50056a016
CAPELLE N, 1980, B SOC CHIM BELG, V89, P399
DESILVA ED, 1982, HETEROCYCLES, V17, P167
Gonzalez MA, 2008, TETRAHEDRON, V64, P445, DOI 10.1016/j.tet.2007.10.057

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